摘要
目的:系统评价渴络欣胶囊联合常规西药治疗糖尿病肾病的有效性及安全性。方法:以PubMed、中国知网、万方数据库等数据库为资料来源,检索自建库至2021年2月收录的渴络欣胶囊联合常规西药治疗糖尿病肾病的临床随机对照试验。设立纳入和排除标准,按照Cochrane偏倚风险评判标准对文献进行质量评价,采用RevMan 5.3软件进行Meta分析。结果:共纳入16篇文献,包括1 384例患者。Meta分析结果显示:渴络欣胶囊联合常规西药在降低24 h尿蛋白、尿白蛋白排泄率、尿素氮、血肌酐、血清白蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇,以及升高高密度脂蛋白胆固醇、提高临床总有效率方面均优于单用西药组(P均<0.01),渴络欣胶囊联合常规西药在降低空腹血糖方面与常规西药相比无明显差异。在最终纳入的研究中,均未发现明显的不良反应与肝肾功能异常。结论:渴络欣胶囊联合常规西药可有效改善糖尿病肾病患者的肾功能和血脂代谢,具有良好的安全性,推荐临床使用。
Objective:To systematically evaluate the efficacy and safety of the Keluoxin capsules(渴络欣胶囊)plus conventional Western medicine on diabetic kidney disease.Methods:Clinical randomized controlled trials about the Keluoxin capsules plus conventional Western medicine in the treatment of diabetic kidney disease were retrieved in PubMed,CNKI,Wanfang and other databases from the establishment of the database to February 2021.We set the inclusion and exclusion criteria.The quality of the literature was evaluated according to the evaluation criteria of Cochrane bias risk,and RevMan 5.3 software was used for a meta-analysis.Results:A total of 16 articles with 1384 patients was included.According to the meta-analysis,the Keluoxin capsules plus conventional Western medicine could reduce 24-hour urinary protein,urinary albumin excretion rate,blood urea nitrogen and serum creatinine,serum albumin,total cholesterol,triglyceride,LDL cholesterol,and increase HDL cholesterol and total effective rate,with a better effect than the Western medicine group alone(all P<0.01).While there was no significant difference between the Keluoxin capsules and conventional western medicine in reducing fasting blood glucose.And in the included studies,no obvious adverse reactions and abnormal liver and kidney function were found.Conclusion:The Keluoxin capsules plus conventional Western medicine can effectively improve renal function and blood lipid metabolism in patients with diabetic kidney disease,with good safety,and is recommended clinical application.
出处
《中医临床研究》
2022年第26期130-136,共7页
Clinical Journal Of Chinese Medicine
基金
杭州师范大学科研启动金(2018QDL038)。
关键词
渴络欣胶囊
糖尿病肾病
肾功能
系统评价
META分析
The Keluoxin capsules
Diabetic kidney disease
Renal function
System evaluation
Meta-analysis