急性心肌梗死经皮冠状动脉介入术治疗前后血清内皮细胞钙黏蛋白水平、血管生成素-2水平与预后相关性分析

Correlation between serum levels of VE-Cad,Ang-2 before and after PCI and prognosis of AMI patients

目的:探析急性心肌梗死(AMI)经皮冠状动脉介入术(PCI)治疗前后血清内皮细胞钙黏蛋白(VE-Cad)水平、血管生成素-2(Ang-2)水平与预后的相关性。方法:选取急性心肌梗死患者64例作为研究对象,所有患者都给予PCI术治疗,在PCI治疗前与治疗后7 d检测患者的血清VE-Cad水平、Ang-2。随访调查患者的预后并进行相关性分析。结果:64例患者PCI治疗后7 d的血清VE-Cad含量高于PCI治疗前(P<0.05),血清Ang-2含量低于PCI治疗前(P<0.05)。64例患者随访到2022年2月1日,平均随访时间为(24.10±2.49)月,发生主要不良心血管事件(MACE)16例(MACE组),占比25.0%,其中心源性死亡2例、血管重建6例、非致死性心肌梗死5例、心力衰竭3例。Logistic回归模型分析显示血清VE-Cad、Ang-2水平为影响患者MACE预后的重要因素(均P<0.05)。受试者工作特征(ROC)曲线分析显示血清VE-Cad、Ang-2水平预测MACE预后的曲线下面积分别为0.797和0.789。结论:PCI治疗急性心肌梗死能促进血清VE-Cad含量升高与血清Ang-2含量降低,血清VE-Cad、Ang-2水平能有效预测急性心肌梗死患者的预后,也是影响患者的重要因素。

Objective:To investigate and analysis the correlation between serum levels of endothelial cadherin(VE-Cad),angiopoietin-2(Ang-2) before and after percutaneous coronary intervention(PCI) and prognosis of patients with acute myocardial infarction(AMI).Methods:A total of 64 cases of AMI patients were selected and treated with PCI.The serum VE-Cad,Ang-2 levels of the patients were detected before and 7 days after PCI treatment.The prognosis of the patients was followed up and the correlation analysis were carried out.Results:The serum VE-Cad content of 64 patients after PCI treatment were higher than that before PCI treatment(P<0.05),and the serum Ang-2 content of 64 patients were lower than that before PCI treatment(P<0.05).The 64 patients were followed up until 1 February 2022,with the average follow-up time of(24.10±2.49) years.The major adverse cardiovascular events(MACE) occurred in 16 patients(MACE group),accounted for 25.0%.There were 2 cases of cardiac death,6 cases of revascularization,5 cases of non-fatal myocardial infarction,and 3 cases of heart failure.Logistic regression model analysis showed that serum VE-Cad and Ang-2 levels were important factors affecting the prognosis of patients with MACE(all P<0.05).Receiver operating characteristic(ROC) curve analysis showed that the areas under the curve of serum VE-Cad and Ang-2 levels for predicting the prognosis of MACE were 0.797 and 0.789,respectively.Conclusion:PCI treatment of AMI can promote the increase of serum VE-Cad content and the decrease of serum Ang-2 content.Serum VE-Cad and Ang-2 levels can effectively predict the prognosis of AMI patients,and are also important factors affecting patients.