表皮干细胞在皮肤创面修复中的作用与机制研究进展

Research advances on the role and mechanism of epidermal stem cells in skin wound repair

表皮干细胞在皮肤自我更新、创面修复、再上皮化过程中发挥关键作用。单细胞测序、基因敲除等新技术新理念的出现进一步揭示了表皮干细胞维持表皮自我更新、参与创面修复的新机制,为创面修复提供了新思路。该文回顾了近年来关于表皮干细胞的增殖、分化、迁移的机制,通过对表皮干细胞异质性与可塑性相关研究的分析,进一步加深对表皮干细胞生理功能的理解;结合表皮干细胞在创面修复领域中的应用进展,为从事创面修复相关工作的临床与基础研究工作者提供参考。

Epidermal stem cells play an pivotal role in skin self-renewal,wound repair,and re-epithelialization process.The emergence of new technologies and concepts such as single-cell sequencing and gene knockout further revealed a new mechanism of epidermal stem cells in epidermal self-renewal and wound repair,providing new ideas for wound repair.In this review,the mechanisms of proliferation,differentiation,and migration of epidermal stem cells are discussed.Combined with the analysis of researches on stem cell heterogeneity and cell plasticity,the physiological function of epidermal stem cells can be further understood.The application advances of epidermal stem cells in wound repair is also summarized,which would provide some advice for workers engaged in clinical and basic research on wound repair.