摘要
急性胰腺炎(acute pancreatitis,AP)是一种以胰腺炎症为主要特征的急腹症。急性上腹部剧烈疼痛是AP患者的典型临床表现和急诊入院的首要原因。关于AP疼痛的机制研究越来越多地关注胰腺与神经的交互作用—神经源性炎症。探索神经源性炎症在AP疼痛中的作用机制,将为其靶向性镇痛药物的研发提供思路。
Acute pancreatitis(AP)is an acute abdominal disease characterised by inflammation of the pancreas.Acute severe upper abdominal pain is the leading symptom and primary reason for emergence hospital admission of AP patients.Nowadays,more and more research has focused on the cross-talk between the exocrine pancreas and pancreatic projecting neurons(neurogenic inflammation)for pain in AP.Elucidating the molecular mechanisms of neurogenic inflammation for pain in AP will provide insights into targeted analgesics development in this setting.
作者
吴咏姿
韩晨霞
蔡文浩
刘婷婷
黄伟
WU Yongzi;HAN Chenxia;CAI Wenhao;LIU Tingting;HUANG Wei(West China Centre of Exellence for Pancreatits,Institute of Integrated Traditional Chinese and Western Medicine,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;Liverpool Pancreaitis Research Group,Institute of Systems,Molecular and Integative Biology,University of Liverpool,Liverpol L693GE,United Kingdom;West China Biobanks,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;Frontiers Science Center for Disease-related Molecular Network,West China Hospital,Sichuan University,Chengdu 610041,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2022年第9期1165-1168,共4页
Chinese Journal of Bases and Clinics In General Surgery
基金
四川省科技计划项目—重点研发项目(项目编号:2022YFS0419)
国家自然科学基金(项目编号:82104598,81973632)。
关键词
急性胰腺炎
疼痛
神经源性炎症
acute pancreatitis
pain
neurogenic inflammation
