线粒体在脓毒症期间的代谢特点

Metabolic characteristics of mitochondria in sepsis

目的 阐述线粒体在脓毒症期间的代谢特点并综述其细胞机制,为脓毒症的治疗提供新的思路。方法 对脓毒症期间线粒体代谢情况的既往文献和最新研究结果进行综述。结果 目前研究者们对于脓毒症的关注已不仅局限于炎症反应,还包括其导致的全身性代谢紊乱。目前观点认为,脓毒症导致的线粒体损伤是患者细胞代谢紊乱的主要原因之一。在脓毒症期间,患者的物质代谢发生改变,包括有氧糖酵解增加、乳酸堆积、血中脂肪酸和甘油三酯水平升高等。结论 脓毒症期间的代谢改变与线粒体息息相关,这可为脓毒症的治疗提供新的思路。

Objective To elucidate the metabolic characteristics of mitochondria in sepsis and review its cellular mechanism,so as to provide new ideas for the treatment of sepsis. Method The previous literatures and latest research results about mitochondrial metabolism during sepsis were reviewed. Results At present, the researchers were not only concerned about the inflammatory response of sepsis, but also concerned about the systemic metabolic disorder caused by sepsis.It was believed that the damage of mitochondria caused by sepsis was one of the main reasons for the disorder of cell metabolism. During the sepsis, the patient’s metabolism had changed, for example, enhancement of aerobic glycolysis,lactic acid accumulation, elevated levels of fatty acids and triglycerides in blood, and so on. Conclusion Metabolic change during sepsis is related to mitochondria, which can provide some new methods for treatment of sepsis.