三期动态增强MSCT联合血清AFP、TSGF及AFP-L3检测对原发性肝癌的诊断价值

Diagnostic Value of Three-phase Dynamic Enhanced MSCT Combined with AFP,TSGF,and AFP-L3 Detection for Primary Liver Cancer

目的分析三期动态增强MSCT联合AFP、TSGF及AFP-L3检测对原发性肝癌的诊断价值。方法选取本院2017年4月至2019年4月收治的59例原发性肝癌患者作为研究对象,分析不同患者中血清AFP、TSGF及AFP-L3含量;以病理诊断为金标准,比较MSCT、血清AFP、TSGF及AFP-L3检测以及四者联合诊断原发性肝癌的准确性、敏感性、特异性。结果肝癌组患者AFP、TSGF及AFP-L3含量显著高于对照组(P<0.05)。MSCT联合血清AFP、TSGF及AFP-L3诊断原发性肝癌的诊断灵敏性、特异性和准确性分别为明显高于单一的血清AFP、TSGF及AFP-L3及MSCT检测(P<0.05),单独检测时,其灵敏度均低于80%,而联合诊断时,其灵敏性、特异性和准确性均高于98%。结论MSCT检查、血清AFP、TSGF及AFP-L3均可检出肝细胞肝癌,但是四者联合诊断准确率更高,更具有临床应用价值。

Objective To analyze the diagnostic value of three-phase dynamic enhanced MSCT combined with AFP,TSGF and AFP-L3 detection in primary liver cancer.Method 59 patients with primary liver cancer treated in our hospital from April 2017 to April 2019 were selected as the research objects,and the contents of serum AFP,TSGF and AFP-L3 in different patients were analyzed.Pathological diagnosis was used as the gold standard to compare the accuracy,sensitivity,and specificity of MSCT,serum AFP,TSGF,and AFP-L3 detection and the combination of the four in the diagnosis of primary liver cancer.Results The levels of AFP,TSGF and AFP-L3 in patients with liver cancer were significantly higher than those in the control group(P<0.05).The sensitivity,specificity and accuracy of MSCT combined with serum AFP,TSGF and AFP-L3 in the diagnosis of primary liver cancer were significantly higher than those of the single serum AFP,TSGF,AFP-L3 and MSCT tests(P<0.05).In test alone,its sensitivity was less than 80%,and in combined test,its sensitivity,specificity,and accuracy were both higher than 98%.Conclusion MSCT examination,serum AFP,TSGF and AFP-L3 can all detect hepatocellular carcinoma,but the combination of the four has higher diagnostic accuracy,and has more clinical application value.