非酒精性脂肪肝患者合并高血压的相关危险因素分析

Risk factors of patients with both non- alcoholic fatty liver disease and hypertension

目的:分析非酒精性脂肪肝(non-alcoholic fatty liver disease, NAFLD)患者的临床特点,并研究其合并高血压的危险因素。方法:回顾分析2014年1月至2020年12月在南京中医药大学附属医院住院的NAFLD患者的临床资料。根据NAFLD患者是否合并高血压分为NAFLD组和NAFLD合并高血压组,两组间比较用单因素分析(t检验、Mann-Whitney U检验、卡方检验),非条件二分类Logistic回归分析筛选NAFLD合并高血压的危险因素。结果:共纳入符合NAFLD入选标准者351例,其中合并高血压患者163例。两组患者在年龄、体质量指数(body mass index, BMI)、糖尿病、丙氨酸氨基转移酶(alanine transferase, ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase, AST)、谷氨酰转肽酶(gamma-glutamyl transferase, GGT)、总胆固醇(total cholesterol, TC)方面的差异均有统计学意义(P<0.05)。多因素回归分析提示,年龄(OR=1.060,P<0.001)、BMI(OR=1.091,P=0.022)、是否合并糖尿病(OR=1.782,P=0.024)为NAFLD合并高血压的影响因素。结论:高龄、高BMI值及糖尿病是NAFLD合并高血压的危险因素。

Objective: To analyze the clinical features of patients with non-alcoholic fatty liver disease(NAFLD) and to explore the risk factors for NAFLD combined with hypertension. Methods: Clinical data of NAFLD patients admitted to the Affiliated Hospital of Nanjing University of Chinese Medicine from January 2014 to December 2020 were retrospectively analyzed. Comparison between patients with NAFLD with or without hypertension was conducted by univariate analysis, and risk factors for NAFLD combined with hypertension were screened by unconditional binary Logistic regression analysis. Results: A total of 351 patients who met the inclusion criteria were included, including 163 patients with hypertension. Their age, body mass index(BMI), diabetes, alanine transferase(ALT), aspartate aminotransferase(AST), gamma-glutamyl transferase(GGT), total cholesterol(TC) were significantly different(P<0.05). Subsequent multivariate regression analysis showed that age(OR=1.060,P<0.001), BMI(OR=1.091,P=0.022) and diabetes mellitus(OR=1.782,P=0.024) were risk factors of NAFLD with hypertension. Conclusion: Advanced age, high BMI value and diabetes mellitus are the risk factors for NAFLD combined with hypertension.