白蛋白联合蓝光照射治疗新生儿黄疸的疗效和对TBIL、IBIL水平的影响

Efficacy of Albumin in Combination with Blue Light Irradiation in the Treatment of Neonatal Jaundice and Its Effect on TBIL and IBIL Levels

目的研究白蛋白联合蓝光照射治疗新生儿黄疸的疗效和对血清总胆红素(TBIL)、非结合胆红素(IBIL)的效果。方法选取2017年1月至2019年12月我院新生儿黄疸70例,按照随机数字表法分为单一组(n=35)和联合组(n=35),单一组使用蓝光照射,联合组在单一组的基础上使用白蛋白。对比2组疗效、住院天数、黄疸消退时长、血清胆红素(TBIL、IBIL)。结果联合组总有效率94.29%(33/35)较高于单一组77.14%(27/35)(P<0.05);与单一组比较,联合组住院天数、黄疸消退时长短(P<0.05);与单一组比较,联合组TBIL、IBIL低(P<0.05)。结论白蛋白配合蓝光照射对于新生儿黄疸能够加强疗效,减缓胆红素水平的上升,促进黄疸减退,预防胆红素脑病,缩短住院天数。

Objective To study the efficacy of albumin in combination with blue light irradiation in the treatment of neonatal jaundice and the effect on serum total bilirubin(TBIL)and unbound bilirubin(IBIL).Methods 70 cases of neonatal jaundice in our hospital were selected from January 2017 to December 2019 and divided into a single group(n=35)and a combined group(n=35)by the random number table method.The single group was irradiated with blue light,and the combined group was used on a single group basis.Albumin.Efficacy,length of hospital stay,length of jaundice,and serum bilirubin(TBIL,IBIL)were compared between the two groups.Results The overall response rate in the combined group was 94.29%(33/35)and was higher than in the single group 77.14%(27/35)(P<0.05);Compared with the individual grou p,length of hospital stay and length of jaundice in the combined group(P<0.05);Compa red to the individual group,TBIL and IBIL were low in the combined group(P<0.05).Conclusion Albumin com bined with blue light irradiation can enhance the cu rative effect of neonatal jaundice,slow down the rise in bilirubin levels,promote the remission of jaundice,prevent biliru bin encephalopathy,and shorten the length of hospital stay.