对比研究国内外铂类抗肿瘤药物的毒性用药规律与临床效果

A Comparative Study of the Toxic Drug Use Rules and Clinical Effects of Platinum-based Antitumor Drugs at Home and Abroad

目的对国内外铂类抗肿瘤药物的毒性用药规律与临床效果进行探讨。方法选取国内外具有代表性的铂类抗肿瘤药物进行研究,国外代表药物为卡铂药物,国内代表药物为捷佰舒。选择我院2020年3月至2022年5月所收治的肿瘤91例患者作为研究对象,根据入院时间将其分为观察组(n=46)和对照组(n=45),对观察组的患者使用卡铂药物进行治疗,对对照组患者使用捷佰舒药物进行治疗,分别观察两组患者的治疗效果、治疗前后的相关指标变化以及治疗后并发症发生率。结果在治疗效果的比较上,观察组患者的治疗效果明显更好,且在与对照组的数据比较中具有统计学差异(P<0.05);在治疗前,两组患者的相关指标无统计学差异(P>0.05),治疗后观察组患者恢复的明显更好,在与对照组数据比较中具有统计学差异(P<0.05);观察组并发症发生率明显低于对照组,且在数据比较中有统计学差异(P<0.05)。结论以国外铂类抗肿瘤药物为代表的卡铂药物治疗效果更好,能够提升治疗效果,促进患者相关指标的恢复,降低患者的并发症发生率。我国的捷佰舒还需要进一步的完善,对国外先进的医学技术进行学习,为我国患者带来更好的治疗环境,促进社会的和谐发展。

Objective To discuss the toxic use rules and clinical effects of platinum-based antitumor drugs at home and abroad.Methods The representative platinum antitumor drugs at home and abroad were selected for research.The foreign representative drug was carboplatin,and the domestic representative drug was Jiebaishu.91 patients with tumors admitted to our hospital from March 2020 to May 2022 were selected as the research objects,and they were divided into the observation group(n=46)and the control group(n=45)according to the admission time.The patients in the two groups were treated with carboplatin drugs,and the patients in the control group were treated with Jiebaishu drugs.The treatment effect,the changes of related indicators before and after treatment,and the incidence of complications after treatment we re observed in the two groups.Results In the compa rison of the treatment effect,the treatment effect of the observation group was significantly better,and there was a statistical difference in the data comparison with the control group(P<0.05);before treatment,the related indicators of the two groups of patients had no statistics After treatment,the patients in the observation group recovered significantly better,and there was a statistical difference compa red with the data in the control group(P<0.05);the incidence of complications in the observation group was significantly lower than that in the control group,and in There was a statistical difference in the data comparison(P<0.05).Conclusion Carboplatin drugs represented by foreign platinumbased anti-tumor drugs have better thera peutic effect,can improve the thera peutic effect,promote the recovery of related indicators of patients,and reduce the incidence of com plications in patients.my country’s Jiebaishu still needs to be further improved,to learn foreign adva nced medical technology,to bring a better treatment environment for Chinese patients,and to promote the harmonious development of society.