苦参碱在动脉粥样硬化相关疾病中的研究进展

Research progress of matrine in atherosclerosis related diseases

苦参碱是从我国传统中草药苦参的根中提取出来的一种喹嗪类生物碱。动脉粥样硬化是以血管壁纤维增生、慢性炎症、脂质堆积和免疫紊乱为特征的一种病理性疾病。近年来,苦参碱在治疗动脉粥样硬化及其相关疾病方面受到广泛关注。研究表明苦参碱可以通过减少血脂、减缓肥胖、抑制炎症和保护内皮细胞等多种途径在动脉粥样硬化相关疾病中发挥重要作用。本文通过文献梳理,对苦参碱治疗动脉粥样硬化及相关疾病的作用机制进行阐述,为其今后苦参碱在临床治疗中的进一步应用奠定基础。

Matrine is a kind of quinazine alkaloid extracted from the root of the traditional Chinese herb Sophora flavescens.Atherosclerosis is a pathological disease characterized by fibrous proliferation of the vascular wall,chronic inflammation,lipid accumulation and immune disorder.In recent years,matrine in the treatment of atherosclerosis and its related diseases have attracted wide attention.Studies have shown that matrine plays an important role in atherosclerotic diseases by reducing blood lipids,slowing down obesity,inhibiting inflammation and protecting endothelial cells.In this paper,the action mechanism of matrine in the treatment of atherosclerosis and its related diseases is further elaborated to lay a foundation for the application of matrine in clinical treatment in the future.