破解新冠病毒谜题支撑疫情科学防控

From Unknown to Known:The Power of Science in Deciphering SARS-CoV-2 Puzzles

新型冠状病毒肺炎疫情在全球范围内已持续两年多,深刻地影响着人类社会的各个方面。各国科技工作者对新型冠状病毒(简称“新冠病毒”)开展了广泛而深入的研究,在新冠病毒的感染致病机理、诊断技术、疫苗药物等方面取得了积极的进展。经过两年多的全球流行,病毒持续传播与变异,人类面临着疫苗保护力下降、药物有效性不足等诸多挑战。本综述主要介绍我们团队在新冠病毒的发现鉴定、传播途径、诊断新技术、疫苗药物、亚基因组生成调控机制等方面的研究进展,以期为疫情防控提供科技支撑和参考依据。

The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has been lasting for more than two years,which profoundly affects all aspects of human society.Researchers worldwide have carried out extensive and in-depth research on COVID-19 and made significant progress in viral pathogenesis,diagnostic techniques,vaccine and drug development.However,we are still facing challenges after the spreading and mutating of the viruses in the past two years,such as the decline of vaccine protection and inadequate drug effectiveness.This review introduces our teamwork on pathogen identification,viral transmission,novel diagnostic techniques,vaccine and drug development,and the regulatory mechanism of viral subgenomic RNA biogenesis,which will provide scientific insight and support for pandemic control.