直接口服抗凝药在儿童患者中的应用进展

Progress in the Application of Direct Oral Anticoagulants in Pediatric Patients

直接口服抗凝药与华法林相比,其起效快、半衰期短,与食物、药物相互作用小,无需频繁监测凝血指标,但目前说明书中尚缺乏儿科患者的适应证。随着儿童抗凝用药的需求日趋增多,直接口服抗凝药在儿科领域显示出巨大的潜力。笔者通过查阅近年来国内外相关指南、文献,对直接口服抗凝药物在儿童应用的研究进展方面进行综述,以期为我国儿童抗凝药物选择方面提供依据。

Compared with the traditional oral anticoagulant warfarin,the new oral anticoagulants,also called direct oral anticoagu⁃lants,have the advantages of fast onset,short half⁃life,less interactions with food and drugs,and no need to frequently monitor coagu⁃lation indicators.With the increasing demand for anticoagulants in children,direct oral anticoagulants show great potential in the field of pediatrics.This paper reviews the latest guidelines and the research progress of new oral anticoagulants in children in order to provide help for the selection of anticoagulant drugs for children in China.