血清Cr、hs-CRP、Cys-C、SOD水平变化对急、慢性肾功能衰竭病人的鉴别诊断价值

Value of serum Cr,hs-CRP,Cys-C and SOD levels in differential diagnosis of patients with acute and chronic renal failure

目的:分析血清肌酐(Cr)、超敏CRP(hs-CRP)、胱抑素C(Cys-C)、超氧化物歧化酶(SOD)水平变化对急、慢性肾功能衰竭病人的鉴别诊断价值。方法:选择83例急慢性肾功能衰竭病人作为研究对象,其中急性肾功能衰竭病人28例,慢性肾功能衰竭病人55例,同期选择健康体检者101名作为对照组;检测受试者血清Cr、hs-CRP、Cys-C、SOD水平,绘制ROC曲线,分析各指标在预测急性和慢性肾功能衰竭病人中的价值。结果:83例肾功能衰竭病人血清Cr、hs-CRP、Cys-C均明显高于对照组(P<0.01),SOD水平明显低于对照组(P<0.01);急性肾功能衰竭病人血清中Cr、hs-CRP、Cys-C水平均明显低于慢性肾功能衰竭病人(P<0.01),SOD水平明显高于慢性肾功能衰竭病人(P<0.05);Cr和Cys-C指标鉴别诊断急性肾功能衰竭和慢性肾功能衰竭的AUC分别为0.73和0.82,有统计学意义(P<0.01);hs-CRP和SOD指标鉴别诊断急性和慢性肾功能衰竭AUC分别为0.40和0.38,无统计学意义(P>0.05)。结论:血清Cr、Cys-C水平测定鉴别诊断急、慢性肾功能衰竭价值明显优于hs-CRP和SOD水平测定。

Objective:To analyze the value of serum creatinine(Cr),hypersensitive C-reactive protein(hs-CRP),cystatin C(Cys-C),and superoxide dismutase(SOD)levels in the differential diagnosis of patients with acute and chronic renal failure.Methods:A total of 83 patients with renal failure were selected as research objects,and 101 healthy subjects were selected as control group in the same period.The levels of serum Cr,hs-CRP,Cys-C and SOD were detected.The ROC curve was drawn,and the value of each index in predicting acute and chronic renal failure was analyzed.Results:The levels of Cr,hs-CRP and Cys-C in 83 patients with renal failure were significantly higher than those in the control group(P<0.01),and the level of SOD was significantly lower than that in the control group(P<0.01).The levels of serum Cr,hs-CRP and Cys-C in patients with acute renal failure were significantly lower than those in patients with chronic renal failure(P<0.01),and the level of SOD was significantly higher than that in patients with chronic renal failure(P<0.05).The AUC of Cr and Cys-C in the differential diagnosis of acute and chronic renal failure was 0.73 and 0.82,respectively,the difference of which was statistically significan(P<0.01).The AUC of hs-CRP and SOD in differential diagnosis of acute and chronic renal failure was 0.40 and 0.38,respectively,the difference of which was not statistically significance(P>0.05).Conclusions:The value of serum Cr and Cys-C levels in differential diagnosis of acute and chronic renal failure was significantly better than that of hs-CRP and SOD levels.