注射用盐酸丙帕他莫致严重双上肢静脉血栓2例分析

Pharmacovigilance of propacetamol hydrochloride for injection

目的通过2例使用盐酸丙帕他莫致严重药品不良反应分析,提出该药的用药警戒。方法对2例使用注射用盐酸丙帕他莫致严重双上肢静脉血栓的病例进行回顾性分析。结果注射用盐酸丙帕他莫配置浓度过低、滴注速度过慢以及疗程过长导致患者发生严重双上肢静脉血栓。结论医师用药前要仔细询问患者过敏史,给予合理的剂量,合理的给药途径,严格按照注射用盐酸丙帕他莫说明书要求配置和输注,所用溶媒为氯化钠注射液100 mL,输注时间为15 min,不得长期使用。

Objective To provide pharmacovigilance of propacetamol hydrochloride for injection by 2 cases of severe adverse drug reactions.Methods A retrospective analysis was performed on 2 cases of severe bilateral upper limb venous thrombosis caused by propacetamol hydrochloride for injection.Results The heavy concentrations,fast intravenous infusion and long course of treatment of propacetamol hydrochloride for injection lead to patient severe bilateral upper limb venous thrombosis.Conclusion Patients’allergy history should be carefully asked before any treatment of drugs with a reasonable dose and a reasonable route.Clinical using of propacetamol hydrochloride for injection should be strictly followed its instructions.The solvent should be NS 100ml and the infusion time is 15 minutes.Long-term and offlabel indications should be forbidden.