雌激素相关受体调控细胞代谢及与肿瘤发生发展关联的研究进展

Research progress on the regulation of cell metabolism by estrogen-related receptors and their association with tumorigenesis and progression

雌激素相关受体(estrogen-related receptors,ERRs)是核受体超家族的重要成员,在细胞能量平衡、代谢、生长发育、免疫等方面起着重要的调控作用。近年来的研究发现,在细胞缺氧状态下,ERRs在棕色脂肪细胞线粒体氧化功能的调节和缺氧诱导因子相关的代谢控制中起着重要作用。ERRα和ERRγ已被证实参与调控心肌细胞代谢相关基因的表达。ERRs在肿瘤细胞代谢调控中也起着至关重要的作用。大量研究证实,ERRα与乳腺癌、前列腺癌、结肠癌等肿瘤的发生发展密切相关。本文就ERRs调控细胞代谢及与肿瘤发生发展关联的研究进展作一概要介绍。

The nuclear receptors super-family includes the estrogen-related receptors(ERRs) that have diverse roles in control of cellular energy balance,general metabolism,growth and development,immunity and so on.Newer findings indicate their important roles in the regulation of brown adipocyte tissue mitochondrial oxidative functions as well as metabolic control in association with hypoxia-inducible factors during cellular hypoxic state.ERRα and ERRγ have been confirmed to be involved in regulating the expression of genes related to metabolism in cardiomyocytes.ERRs also play a crucial role in the regulation of tumor cell metabolism.A large number of studies have confirmed that ERRα is closely related to the occurrence and development of breast cancer,prostate cancer,colon cancer and other tumors.This article briefly introduces the research progress on the regulation of cell metabolism by ERRs and their association with tumorigenesis and progression.