精准医学下的免疫联合疗法在肝癌中的应用研究进展

Research progress in the application of immunotherapy combined with precision medicine in managing liver cancer

肝癌恶性程度高,预后差。肝癌恶性生物学行为以及肿瘤高度异质性造成了其疗效差异。肝癌的精准治疗蓬勃发展。本文对精准医学下免疫检查点抑制剂联合疗法,包括免疫检查点抑制剂联合靶向治疗、放疗、化疗、溶瘤病毒、肿瘤疫苗、粪菌移植等进行综述。

Liver cancer has a high degree of malignancy and its prognosis is poor.The biological behavior of liver cancer with its high degree of malignancy and high tumor heterogeneity impact on its therapeutic effect.The rapid development of precision therapy in the field of cancer provides a platform for application of the precision therapy mode in liver cancer treatment.This article reviews the combined impact by using immune checkpoint inhibitors therapy under precision medicine with targeted therapy,radiotherapy,chemotherapy,oncolytic viruses,tumor vaccines,fecal bacteria transplantation and other therapies.