糖皮质激素诱导细胞凋亡的研究进展

Research advances in glucocorticoid-induced apoptosis

细胞凋亡从胚胎发育到生物体的整个生长过程中都是至关重要的,有助于组织的更新以及消除炎症细胞。糖皮质激素在不同组织细胞中表现出促凋亡和抗凋亡作用。虽然近几年其诱导凋亡研究进展得到长足的发展,但是详细机制过程至今仍旧不清楚。本文将重点介绍糖皮质激素促进细胞凋亡的机制,并指出了其在各个系统中分子生物学的主要研究进展。

Apoptosis is vital in the entire growth process from embryo to biosome,which is conducive to tissue renewal and elimination of inflammatory cells.Glucocorticoids have the effects of promoting apoptosis and anti-apoptosis in different tissues and cells.Although the research progress of its induced apoptosis has made great advance in recent years,the concrete mechanism isn't still clarity.This paper emphatically introduces the mechanism of promoting apoptosis of glucocorticoids,and points out its main research content in the molecular biology in each system.