结核分枝杆菌Mce4蛋白家族研究进展

Research progress on the Mce4 protein family of Mycobacterium tuberculosis

由结核分枝杆菌引起的结核病自2007年以来一直位居单一传染性疾病死因之首。结核病流行的主要原因是由于结核分枝杆菌能在宿主细胞内长期休眠,对宿主防御和药物治疗具有很强的抵抗力。结核分枝杆菌的哺乳动物细胞入侵(mammalian cell entry,Mce)蛋白家族在其侵袭和细胞内存活中起着重要作用,Mce蛋白家族有4个mce操纵子(mce1-4)编码。其中,mce4操纵子及其编码的Mce4蛋白家族在诱导病原菌入侵、调控宿主免疫、摄取利用胆固醇的过程中至关重要。笔者综述了mce4操纵子及Mce4蛋白家族的研究进展,以便对Mce4蛋白在结核分枝杆菌发病机制中的作用有更深入的认识。同时,也能为结核病的治疗提供潜在的新靶点。

Tuberculosis(TB)caused by Mycobacterium tuberculosis has been the first cause of death for single infectious diseases since 2007.An indispensable cause of TB epidemic is that M.tuberculosis can dormant in host cells for a long time,and it has strong resistance to host defense and drug treatment.Mammalian cell entry(Mce)protein family plays a major role in M.tuberculosis invasion and intracellular survival.Among them,the mce operons(mce1-4)and the encoded Mce4 protein family are essential in the process of inducing pathogenic bacteria invasion,regulating host immunity,and ingesting and utilizing cholesterol.The authors reviews the research progress of mce4 operon and Mce4 protein family,to further comprehend the role of Mce4 proteins in the pathogenesis of M.tuberculosis and provide potential new targets for the treatment of tuberculosis.