胰岛素受体底物氨基酸相互作用网络鲁棒性研究

Robustness of Insulin Receptor Substrate Amino Acid Interaction Network

为了研究胰岛素受体底物2(IRS2)与胰岛素受体底物1(IRS1)在调节胰岛素对肝脏新陈代谢的作用差异,本文根据复杂网络思想,构建IRS1和IRS2的氨基酸酸相互作用网络,研究两者的鲁棒性差异。通过度攻击、随机攻击、介数攻击、接近程度攻击4种方式攻击两者的氨基酸相互作用网络,实验表明,在4种方式的攻击下,IRS2的网络鲁棒性均优于IRS1,表明IRS2的氨基酸相互作用网络更加稳定,容错性更高,推测IRS2比IRS1在调节胰岛素对肝脏新陈代谢中起着更重要的作用。

In order to study the difference of insulin receptor substrate 2(IRS2)and insulin receptor substrate 1(IRS1)in regulating insulin metabolism in liver,the complex network theory was used to construct the amino acid interaction network of IRS1and IRS2,and then study the robustness difference between them.Through degree attack,random attack,betweenness attack and proximity attack,the network robustness of IRS2is better than that of IRS1,which indicates the amino acid interaction network of IRS2is more stable and error tolerant.It is thus speculated that IRS2plays a more important role in regulating insulin metabolism in liver than IRS1.