摘要
Peptaibols are a large family of linear,amphipathic polypeptides consisting of 5-20 amino acid residues gener-ated from the fungal nonribosomal peptide synthetase(NRPS)pathway.With a relatively high content of non-proteinogenic amino acids such as𝛼-aminoisobutyrate(Aib)and isovaline(Iva)in the skeleton,peptaibols exhibit a wide range of biological activities,including anti-microbial,cytotoxic,and neuroleptic effects.With five peptai-bols brought to market for use as biocontrol agents,this class of peptides has received increasing attention from both biochemists and pharmacologists.In this review,we summarized the progress made in structural character-ization,elucidation of biosynthetic pathways,and investigation of biosynthesis elucidation and bioactivities,to promote further efforts to develop peptaibols as pharmaceuticals.
基金
This work was funded by National Natural Science Foundation of China(Nos.41976105,81991522)
Taishan Scholar Youth Expert Pro-gram in Shandong Province(No.tsqn 202103153)
Major Basic Re-search Programs of Natural Science Foundation of Shandong Province(No.ZR2019ZD18)
the Fundamental Research Funds for the Cen-tral Universities(No.201941001)
the NSFC-Shandong Joint Fund(No.U1906212)
the Marine S&T Fund of Shandong Province for Pi-lot National Laboratory for Marine Science and Technology(Qingdao)(No.2018SDKJ0401-2)
the Youth Innovation Plan of Shandong province(No.2019KJM004).
