摘要
In a very recent article published in Science,Altae-Tran et al.recon-structed the evolution of CRISPR-Cas9 systems and traced their ances-tors to unique groups of transposons(Altae-Tran et al.,2021).These transposable elements encode RNA-guided nucleases that show strong potential for developing novel biotechnologies.Structural domains of these nucleases serve as useful building blocks for engineering novel RNA-guided nucleases via synthetic biology to strongly inspire the de-velopment of novel and precision genome-editing tools.
基金
supported by grants from the National Key R&D Program of China(2020YFA0906800 to QS)
the National Natural Science Foundation of China(Grant No.31771380 to QS)
State Kay Laboratory of Microbial Technology at Shandong University.
