耳甲电针联合柴胡疏肝散对功能性消化不良患者胃肠激素水平及生活质量的影响

Effect of ear-concha electroacupuncture combined with Chaihu Shugan powder on the level of gastrointestinal hormones and quality of life in patients with functional dyspepsia

目的:研究耳甲电针联合柴胡疏肝散对功能性消化不良(FD)患者胃肠激素水平及生活质量的影响。方法:收集2019年3月—2022年3月接诊的102例FD患者,随机分为对照组(51例,常规西药)与联合组(51例,耳甲电针+柴胡疏肝散),治疗前后应用功能性消化不良生存质量量表(FDDQL)、焦虑自评量表(SAS)、抑郁自评量表(SDS)评估患者的生活质量、焦虑、抑郁情况,检测胃肠激素水平,观察中医症状积分改善情况,完成疗效评估,记录不良反应。结果:治疗后,联合组与对照组的总有效率分别为92.16%和74.51%,差异有统计学意义(P<0.05)。联合组胃脘胀满、口干苦、纳呆、便溏、嘈杂积分均显著低于对照组(均P<0.05);治疗后,联合组FDDQL评分显著高于对照组,SAS及SDS评分显著低于对照组(均P<0.05);联合组治疗后血浆胃动素水平显著高于对照组,血浆胆囊收缩素及血清胃泌素水平显著低于对照组(均P<0.05)。联合组不良反应总发生率为3.92%,对照组为15.69%,差异有统计学意义(P<0.05)。结论:耳甲电针联合柴胡疏肝散治疗FD可改善患者的胃肠激素水平,减轻患者胃脘胀满、口干苦等症状,缓解负面情绪并提高生活质量,且安全性较常规西药更高。

Objective: To study the effect of ear-concha electroacupuncture combined with Chaihu Shugan powder on the levels of gastrointestinal hormones and quality of life in patients with functional dyspepsia(FD).Methods: A total of 102 FD patients admitted to our hospital from March 2019 to March 2022 were collected and randomly divided into the control group(51 cases,conventional western medicine)and the combined treatment group(51 cases,ear-concha electroacupuncture+Chaihu Shugan powder),functional digestive disorders quality of life questionnaire(FDDQL),self-rating anxiety scale(SAS),self-rating depression scale(SDS)were applied before and after treatment.Rating SDS to evaluate patients'quality of life,anxiety and depression,measure gastrointestinal hormone levels,observe the improvement of Traditional Chinese Medicine symptom scores,complete efficacy evaluation,and record adverse reactions.Results: After treatment,the total effective rates of the combined group and the control group were 92.16%and 74.51%,respectively,and the difference was statistically significant(P<0.05).were significantly lower than those in the control group(P<0.05);after treatment,the FDDQL score of the combined group was significantly higher than that of the control group,and the SAS and SDS scores were significantly lower than those of the control group(P<0.05).The levels of motilin(MTL)were significantly higher than those in the control group,and the levels of plasma cholecystokinin(CCK)and serum gastrin(GAS)were significantly lower than those in the control group(P<0.05);adverse reactions in the combination group the total incidence was 3.92%,and the control group was 15.69%(P<0.05).Conclusion: Ear-concha electroacupuncture combined with Chaihu Shugan powder in the treatment of FD can improve the gastrointestinal hormone levels of patients,relieve the symptoms of dry mouth and fullness of the stomach,relieve negative emotions and improve the quality of life,and it is safer than conventional western medicine treatment higher.