小檗碱药理作用及其相关作用机制研究进展

Research progress on pharmacological action and related mechanism of berberine

小檗碱是许多中药的一种常见活性物质,数千年来被广泛应用于消化系统相关疾病。现代药理研究表明小檗碱在预防和保护代谢性疾病及主要脏器损伤等方面也具有显著的药理活性。因此,在前期文献研究的基础上,整理和总结了近年小檗碱在脏器损伤如神经损伤、肝脏损伤、肾脏损伤、生殖系统损伤、胃肠道损伤、心血管疾病以及代谢性疾病如阿尔茨海默症、糖尿病及相关并发症、炎症等疾病的保护作用及其相关机制,并针对亟需解决的的问题提出了建议,以期为小檗碱的临床安全使用和新药研发提供参考。

Berberine is a common active substance in many traditional Chinese medicine, which was widely used to treat the digestive system related diseases for thousands of years. Modern pharmacological studies showed that berberine also has significant pharmacological activities in preventing and protecting main organs damage, including nerve damage, heart damage, kidney damage,reproductive system damage, gastrointestinal tract damage, and metabolic disease, including Alzheimer’s disease, diabetes and related complications, as well as the inflammation. Therefore, based on the previous research, pharmacological activities of berberine in organ injury such as nerve damage and liver damage as well as the metabolic diseases were organized and summarized in this paper, and some suggestions were made to solve the urgent problems, in order to provide reference for safe use of berberine in clinic and the development of new drugs in the future.