芪菊袋泡茶鼻负压置换疗法治疗儿童慢性鼻窦炎疗效观察

Observation on Curative Effect of Nasal Cavity Negative Pressure Replacement Therapy with Soaking Solution of Qiju Tea Bags for the Treatment of Chronic Rhinosinusitis in Children

【目的】探讨芪菊袋泡茶鼻负压置换疗法治疗慢性鼻窦炎气阴两虚、热毒蕴结证患儿的临床疗效。【方法】将60例慢性鼻窦炎气阴两虚、热毒蕴结证患儿随机分为对照组和观察组,每组各30例。2组患儿均给予常规西药治疗(包括小剂量阿奇霉素干混悬剂口服和糠酸莫米松鼻喷雾剂喷鼻治疗),在此基础上,对照组给予0.9%氯化钠注射液行鼻负压置换疗法治疗,观察组给予芪菊袋泡茶浸泡液行鼻负压置换疗法治疗,隔两天治疗1次,疗程为2周。观察2组患儿治疗前后主要症状、体征评分和鼻内镜检查Lund-Kennedy评分的变化情况,并评价2组患儿的临床疗效和安全性。【结果】(1)疗效方面,治疗2周后,观察组的总有效率为96.7%(29/30),对照组为73.3%(22/30),组间比较,观察组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)Lund-Kennedy评分方面,治疗2周后,2组患儿的Lund-Kennedy评分均较治疗前明显下降(P<0.01),且观察组对Lund-Kennedy评分的下降作用明显优于对照组,差异有统计学意义(P<0.01)。(3)症状、体征评分方面,2组患儿的鼻塞、流脓涕、回吸痰、鼻黏膜充血肿胀评分及观察组的头痛、嗅觉减退评分,治疗1周后比治疗前、治疗2周后比治疗1周后,其评分均有下降(P<0.05),且观察组在治疗1周后和治疗2周后对各项症状、体征评分的下降作用均明显优于对照组,差异均有统计学意义(P<0.05)。(4)治疗期间,2组患儿均未出现明显不良反应,且患儿的肝肾功能指标均无异常变化。【结论】在常规西药治疗基础上,应用芪菊袋泡茶鼻负压置换疗法治疗慢性鼻窦炎气阴两虚、热毒蕴结证患儿疗效确切,能有效改善患儿的症状、体征评分和鼻内镜检查Lund-Kennedy评分。

Objective To investigate the clinical efficacy of nasal cavity negative pressure replacement therapy with the soaking solution of Qiju Tea Bags for the treatment of chronic rhinosinusitis(CRS)in children with the syndrome of qi-yin deficiency and heat-toxin accumulation.Methods Sixty CRS children with the syndrome of qiyin deficiency and heat-toxin accumulation were randomly divided into the control group and the observation group,with 30 cases in each group.Patients of both groups were given oral use of small-dosage of Azithromycin for Suspension and nasal spray therapy with Mometasone Furoate Nasal Spray.And additionally,the control group was given nasal cavity negative pressure replacement therapy with the 0.9%sodium chloride injection and the observation group was given nasal cavity negative pressure replacement therapy with the soaking solution of Qiju Tea Bags once every three days for two weeks.The changes in the scores of primary symptoms and signs and the scores of Lund-Kennedy assessment with nasal endoscope in the two groups before and after treatment were observed.Meanwhile,the clinical efficacy and safety in the two groups were also evaluated after the treatment.Results(1)After 2 weeks of treatment,the total effective rate in the observation group was 96.7%(29/30),and that in the control group was 73.3%(22/30).The intergroup comparison showed that the clinical efficacy of the treatment group was superior to that of the control group(P<0.05).(2)After 2 weeks of treatment,the LundKennedy scores in the two groups were obviously decreased compared with those before treatment(P<0.01),and the effect on decreasing Lund-Kennedy scores in the treatment group was superior to that in the control group(P<0.01).(3)The scores of nasal obstruction,purulent nasal discharge,nasal sputum,and nasal mucosal congestion and swelling in the two groups and the scores of headache and dysosmia after one week of treatment were decreased in comparison with those before treatment,and the scores after 2 weeks of treatment were decreased in comparison with those after one week of treatment(P<0.05).The intergroup comparison showed that after one week and 2 weeks of treatment,the treatment group had stronger effect on decreasing the scores of the primary symptoms and signs than the control group,and the differences were statistically significant(P<0.05).(4)During the treatment,no obvious adverse reation or abnormal hepatic and renal function occurred in the two groups.Conclusion In addition to conventional western medicine treatment,nasal cavity negative pressure replacement therapy with the soaking solution of Qiju Tea Bags exerts certain effects in treating CRS children with the syndrome of qi-yin deficiency and heat-toxin accumulation,and the combined therapy is effective on improving the symptom and sign scores and nasal endoscopy Lund-Kennedy scores.