摘要
唾液酸结合免疫球蛋白样凝集素15(Siglec-15)是在巨噬细胞上表达的免疫抑制因子,在肿瘤相关巨噬细胞(TAM)介导的T细胞免疫中发挥重要作用。Siglec-15具有特殊的生物学特征,具有诱导肿瘤免疫逃逸的作用,并可调节肿瘤微环境(TME)免疫以及重置或重编码TME中抗肿瘤免疫等方面的作用。本文就Siglec-15影响恶性肿瘤免疫的研究进展综述如下。
Sialic acid-binding immunoglobulin-like lectin 15(Siglec-15)is an immunosuppressive factor expressed on macrophages and plays an important role in T-cell immunity mediated by tumor associated macrophage(TAM).Siglec-15 has special biological characteristics,has the effect of inducing tumor immune escape,and can regulate the role of anti-tumor immunity in tumor microenvironment(TME).In this paper,the research progress of Siglec-15 affecting malignant tumor immunity is summarized as follows.
作者
杨培伟
刘光伟
赵文霞
Yang Peiwei;Liu Guangwei;Zhao Wenxia(The Department of Hepatology and Spleen-Stomach,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)
出处
《消化肿瘤杂志（电子版）》
2022年第2期109-112,共4页
Journal of Digestive Oncology(Electronic Version)
基金
国家自然科学基金(82003994)
河南省中医药科学研究专项课题(2019JDZX2034)
中国博士后科学基金第71批面上项目(2022M711082)。
