PD-1在预测卵巢癌患者预后中的作用

The role of PD-1 in predicting the prognosis of ovarian cancer patients

目的探讨程序性死亡受体1(PD-1)在预测卵巢癌患者预后中的作用。方法选取70例卵巢癌患者作为恶性组,另选取70例同期良性卵巢肿瘤患者作为良性组。两组均应用免疫组化检测PD-1表达水平,对比两组患者PD-1蛋白阳性表达率。对恶性组患者进行1年随访,根据预后结果分为死亡组(17例)和存活组(53例),对比两组患者的临床特征,采用Logistic回归分析卵巢癌预后的影响因素。结果恶性组患者PD-1蛋白阳性率62.86%明显高于良性组的28.57%,差异具有统计学意义(P<0.05)。存活组FIGO分期Ⅰ~Ⅱ期38例、Ⅲ~Ⅳ期15例,淋巴结转移6例、未转移47例,组织分化程度低分化31例、中分化18例、高分化4例,PD-1表达阳性29例、阴性24例;死亡组FIGO分期Ⅰ~Ⅱ期7例、Ⅲ~Ⅳ期10例,淋巴结转移11例、未转移6例,组织分化程度低分化5例、中分化6例、高分化6例,PD-1表达阳性15例、阴性2例。存活组与死亡组患者FIGO分期、淋巴结转移情况、组织分化程度、PD-1表达情况对比,差异具有统计学意义(P<0.05)。Logistic回归分析结果显示,淋巴结转移情况与PD-1表达情况为卵巢癌预后独立危险因素(P<0.05)。结论卵巢癌患者组织中PD-1表达明显增高,且PD-1表达与卵巢癌患者病理特征中的淋巴结转移情况具有一定关系,而且是患者预后的独立危险因素。

Objective To explore the role of programmed death-1(PD-1)in predicting the prognosis of ovarian cancer patients.Methods 70 patients with ovarian cancer were selected as malignant group,and another 70 patients with benign ovarian tumors during the same period were selected as benign group.The expression levels of PD-1 were detected by immunohistochemistry in both groups,and the positive expression rates of PD-1protein were compared between the two groups.Patients in the malignant group were followed up for 1 year and divided into the death group(17 cases)and the survival group(53 cases)according to the prognosis.The clinical characteristics of the two groups were compared,and Logistic regression analysis was used to analyze the factors affecting the prognosis of ovarian cancer.Results The positive rate of PD-1 protein in the malignant group was 62.86%,which was significantly higher than 28.57% in the benign group,and the difference was statistically significant(P<0.05).In the survival group,there were 38 cases of FIGO stage Ⅰ-Ⅱ and 15 cases of stage Ⅲ-Ⅳ;6 cases of lymph node metastasis and 47 cases of non-metastasis;31 cases of low differentiation,18 cases of intermediate differentiation and 4 cases of high differentiation;29 cases of positive PD-1 expression and 24 cases of negative PD-1 expression.In the death group,there were 7 cases of FIGO stage Ⅰ-Ⅱ and 10 cases of stage Ⅲ-Ⅳ;11 cases of lymph node metastasis and 6 cases of non-metastasis;5 cases of low differentiation,6 cases of medium differentiation and 6 cases of high differentiation;15 cases of positive PD-1 expression and 2 cases of negtive PD-1 expression.The differences in FIGO staging,lymph node metastasis,degree of tissue differentiation and PD-1 expression between the survival group and the death group were statistically significant(P<0.05).Logistic regression analysis showed that lymph node metastasis status and PD-1 expression status were independent risk factors for the prognosis of ovarian cancer(P<0.05).Conclusion The expression of PD-1 in the tissues of patients with ovarian cancer was significantly increased,and the expression of PD-1 has a certain relationship with the lymph node metastasis in the pathological characteristics of patients with ovarian cancer,and is a independent risk factor of the prognosis of patients.