缩宫素、宫腔填纱联合卡前列素氨丁三醇预防前置胎盘剖宫产产后出血的效果观察

Effect of oxytocin and intrauterine gauze packing combined with carboprost tromethamine in preventing postpartum hemorrhage caused by placenta previa at cesarean section

目的分析缩宫素、宫腔填纱联合卡前列素氨丁三醇对前置胎盘剖宫产患者产后出血的预防效果。方法84例前置胎盘剖宫产患者,随机分为参照组和观察组,每组42例。参照组给予缩宫素和宫腔填纱,观察组在参照组基础上给予卡前列素氨丁三醇。比较两组产后出血量、不良反应发生情况、生活质量评分。结果观察组患者产后2 h出血量(376.25±32.94)ml、产后4 h出血量(419.85±32.74)ml、产后12 h出血量(523.98±57.61)ml均少于参照组的(946.81±109.25)、(1083.91±121.06)、(1214.86±128.59)ml,差异均有统计学意义(t=32.405、34.317、31.776,P=0.000、0.000、0.000<0.05)。观察组不良反应发生率为23.81%,与参照组的28.57%比较,差异无统计学意义(χ^(2)=0.246,P=0.620>0.05)。治疗后,观察组的心理健康、身体健康、精神状态、社交功能评分分别为(81.34±5.17)、(80.56±6.47)、(83.58±6.37)、(80.69±5.31)分,均高于参照组的(72.39±5.28)、(73.85±6.14)、(71.06±6.29)、(72.81±5.23)分,差异具有统计学意义(P<0.05)。结论缩宫素、宫腔填纱联合卡前列素氨丁三醇用于预防前置胎盘剖宫产产后出血能够提高止血效果,促进患者术后恢复,且治疗方法安全可靠,具有临床推广价值。

Objective To analyze the effect of oxytocin and intrauterine gauze packing combined with carboprost tromethamine in preventing postpartum hemorrhage caused by placenta previa at cesarean section.Methods A total of 84 patients with postpartum hemorrhage caused by placenta previa at cesarean section were randomly divided into reference group and observation group,with 42 cases in each group.The reference group was treated with oxytocin and intrauterine gauze packing,and the observation group was treated with carboprost tromethamine on the basis of the reference group.The amount of postpartum hemorrhage,occurrence of adverse reactions,and quality of life score were compared between the two groups.Results The blood loss at 2,4 and 12 h after delivery in the observation group were(376.25±32.94),(419.85±32.74)and(523.98±57.61)ml,which were lower than(946.81±109.25),(1083.91±121.06)and(1214.86±128.59)ml in the control group,and the differences were statistically significant(t=32.405,34.317,31.776;P=0.000,0.000,0.000<0.05).The incidence of adverse reactions in the observation group was 23.81%,and the difference was not statistically significant compared with 28.57%in the reference group(χ^(2)=0.246,P=0.620>0.05).After treatment,the scores of mental health,physical health,mental state,and social function in the observation group were(81.34±5.17),(80.56±6.47),(83.58±6.37),and(80.69±5.31)points,which were higher than(72.39±5.28),(73.85±6.14),(71.06±6.29),and(72.81±5.23)points in the reference group,and the differences were statistically significant(P<0.05).Conclusion Oxytocin,intrauterine gauze packing combined with carboprost tromethamine for preventing postpartum hemorrhage caused by placenta previa at cesarean section can improve the hemostatic effect and promote postoperative recovery of patients,and the treatment method is safe and reliable,and has clinical promotion value.