肿瘤相关巨噬细胞靶向治疗研究进展

Advances in Targeted Therapy of Tumor-Associated Macrophages

肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)是肿瘤微环境(tumor microenvironment,TME)中浸润最丰富的免疫细胞群。临床上,TAMs的数量与多种癌症患者的不良预后密切相关。在肿瘤进展的各个阶段,TAMs发挥着重要作用。多项研究表明,降低TAMs的密度或作用可抑制肿瘤生长。随着TAMs与恶性肿瘤关系逐渐明晰,TAMs已被视为癌症治疗的潜在靶点。本文就TAMs的来源、分类、在人类恶性肿瘤中的作用、靶向TAMs的治疗方法等进行综述。

Tumor-associated macrophages(TAMs)are the most widely infiltrating immune cells in the tumor microenvironment(TME).Clinically,the number of TAMs is closely related to the poor prognosis of many cancer patients.TAMs play an important role in various stages of tumor progression.A number of studies have demonstrated that reducing the density or effects of TAMs can inhibit the growth of tumors.As the relationship between TAMs and malignant tumors becomes more and more clear,TAMs has been regarded as a potential target for cancer therapy.This review summarizes the origin,classification,role in tumor growth about TAMs,and the therapeutic strategies of Targeting TAMs.