中药防治糖尿病并发抑郁症药理作用和临床应用的研究进展

Research progress on pharmacologic effects and clinical application of traditional Chinese medicine in prevention and treatment of diabetic depression

抑郁症具有发病率高、致残率高和致死率高的巨大社会危害性,且在糖尿病人群中发病率是在正常人群的2~3倍,两者合并引发且加重了患者多种机体功能和心理障碍,使其自杀率增高。中药防治糖尿病并发抑郁症具有整体论治、不良反应小、疗效显著的优势,然而其科学内涵不十分清晰,现代研究与推广应用仍十分薄弱。综述了糖尿病并发抑郁症的发病机制和中药复方、单味中药、中药有效成分防治糖尿病并发抑郁症的现代动物研究和临床研究。结合中药在防治糖尿病并发抑郁症方面的现代研究概况,提出今后应以复方的临床效用为指导,加强有效复方中“君”“臣”“佐”“使”药及其有效成分防治糖尿病并发抑郁症的基础实验研究,为中药复方的物质基础和作用靶点的阐明提供依据,为糖尿病并发抑郁症的实验研究和临床应用推广提供一定的参考价值。

Depression has the huge social harm of high incidence, high disability, and high fatality rate, and its incidence rate in the diabetic population is 2 to 3 times of that in the normal population. The combination of the two diseases caused and aggravated a variety of physical functions and psychological disorders in patients, and increased the suicide rate. Traditional Chinese medicine has the advantages of holistic treatment, small side effects, and significant curative effects in the prevention and treatment of diabetic depression. However, its scientific connotation is not very clear, and the relevant modern research and promotion and application are still very weak. Pathogenesis of diabetic depression, and modern animal and clinical research on prevention and treatment of diabetic depression by traditional Chinese medicine prescription, single traditional Chinese medicine, and traditional Chinese medicine ingredients were reviewed in this paper. Combining with modern research status of traditional Chinese medicine in treatment of diabetic depression, it is suggested that clinical effect of traditional Chinese medicine compound should be taken as the guidance in the future, and study on “sovereign”, “minister”, “assistant” and “guiding” medicinal in the effective prescriptions and their active ingredients in prevention and treatment of diabetic depression should be strengthened to provide a basis for the elucidation of material basis and target of traditional Chinese medicine compound, in order to provide a certain reference value for experimental study and clinical application of diabetic depression.