肌少症造模方法的研究进展

Research progress in modeling methods of sarcopenia

肌少症以肌肉质量减少、力量减退、功能下降为主要表现,可增加跌倒和骨折风险,是老年人的常见病和多发病。随着人口老龄化程度的不断加剧,肌少症所带来的问题逐渐突显。明确本病的发病机制至关重要,现有的肌少症造模方案各有利弊,造模时间短、成本低、与人类肌少症病理改变高度一致的动物模型是研究的关键步骤。故查阅近年来国内外文献,总结并探讨肌少症造模方法的研究进展,以期为肌少症的研究提供参考。

Sarcopenia is a common disease and frequently occurring disease in the elderly. The main manifestations of sarcopenia are loss of muscle mass, strength and function, which can increase the risk of falls and fractures.With the aggravation of aging society, sarcopenia brings more and more serious problems. Exploring and clarifying the pathogenesis of sarcopenia has become a current research focus. At present, the modeling of sarcopenia has both advantages and disadvantages, An animal model with short modeling time, low cost and a high degree of consistency with human sarcopenia is a key step in the research. Therefore, the domestic and foreign literature in recent years was reviewed to summarize and discuss the research progress of sarcopenia modeling method, in order to provide reference for sarcopenia modeling.