脂肪细胞分泌的炎症因子及相关信号通路介导的肥胖和胰岛素抵抗

Implication of inflammatory cytokines secreted by adipocytes and associated signaling pathways in obesity and insulin resistance

脂肪组织是机体能量的储存库,也是分泌一系列激素和促炎因子的内分泌器官。在肥胖个体中,脂肪细胞能分泌多种炎症因子,促进巨噬细胞浸润,并通过激活多种炎症相关信号通路,引起脂肪组织中炎症水平增加和胰岛素受体底物1丝氨酸磷酸化,并最终导致胰岛素抵抗的发生。临床研究发现二甲双胍和非甾体类抗炎药等对肥胖诱导的胰岛素抵抗有一定改善作用。本文综述了脂肪来源的炎症因子及其相关的信号通路与肥胖和胰岛素发生发展的关系,并对其预防和治疗策略予以展望。

Adipose tissue is the body’s energy reservoir and the endocrine organ that secretes a series of hormones and proinflammatory factors. In obese individuals, adipocytes can secrete a variety of inflammatory factors that promote macrophage infiltration and increased inflammation levels in adipose tissue and phosphorylation of insulin receptor substrate 1 by activating a variety of inflammation-related signaling pathways, which leads to insulin resistance ultimately. Clinical studies have shown that metformin and non-steroidal anti-inflammatory drugs can improve obesity-induced insulin resistance to some extent. This article reviews the relationship of adipocyte-derived inflammatory factors and their related signaling pathways with obesity and insulin resistance, looking forward to their prevention and treatment strategies.