二甲双胍和阿卡波糖治疗门诊糖尿病患者的疗效、成本和安全性对比

Efficacy,Cost,and Safety of Metformin and Acarbose in Outpatients with Diabetes

目的:比较分析二甲双胍和阿卡波糖治疗门诊糖尿病患者的疗效、成本和安全性。方法:选取2020年5月至2021年5月来四会市中医院医共体总医院黄田分院收治的100例诊糖尿病患者进行治疗,按照不同的治疗方案分为对照组(n=50例)和观察组(n=50例),对照组口服二甲双胍,500mg/次,3次/d,观察组口服阿卡波糖,50mg/次,3次/d,两组均持续给药12周,比较两组的治疗效果、用药成本以及安全性。结果:观察组治疗有效率为98%,对照组治疗有效率为80%,两组对比观察组治疗效果更佳,P<0.05;治疗后两组FPG、2hPG、HbA1c水平较治疗前均明显降低,且观察组的血糖水平更低,P<0.05;相较于治疗前,治疗后两组的总胆固醇水平明显降低,且对照组的总胆固醇降低幅度更大,P<0.05;治疗后,观察组的不良反应发生率为4%,对照组的为20%,观察组不良反应发生率更低,P<0.05,观察组用药成本显著低于对照组,P<0.05。结论:在门诊糖尿病患者的临床治疗中,二甲双胍以及阿卡波糖均为有效药物,其中,二甲双胍也具有显著的降脂效果,且用药成本低;而阿卡波糖血糖控制效果更佳,不良反应少,安全性更高。

Objective:To compare and analyze the efficacy,cost and safety of metformin and acarbose in the treatment of diabetic outpatients.Methods:A total of 100 diabetic patients who came to our outpatient clinic from May 2020 to May 2021 were selected for treatment,and divided into control group(n=50 cases)and observation group(n=50 cases)according to different treatment plans.The group was given oral metformin,500 mg/time,3 times/d,while the observation group was given oral administration of acarbose,50 mg/time,3 times/d.Both groups were given continuous administration for 12 weeks.The therapeutic effect,drug cost and safety of the two groups were compared.Results:The effective rate of treatment in the observation group was 98%,while that in the control group was 80%.The treatment effect of the two groups was better than that of the observation group,P<0.05.The blood glucose level in the group was lower,P<0.05;compared with before treatment,the total cholesterol level in the two groups was significantly reduced after treatment,and the total cholesterol in the control group decreased more significantly,P<0.05;after treatment,adverse reactions occurred in the observation group The incidence of adverse reactions in the observation group was lower,P<0.05,and the cost of medication in the observation group was significantly lower than that in the control group,P<0.05.Conclusion:In the clinical treatment of outpatient diabetes patients,both metformin and acarbose are effective drugs.Among them,metformin also has a significant lipid-lowering effect,and the drug cost is low;while acarbose has better blood sugar control effect and fewer adverse reactions,higher security.