慢性肝病合并情绪障碍患者肝纤维化指标与周围血细胞计数、GGT/PLT的相关性

Correlation of Hepatic Fibrosis Index with Peripheral Blood Count,GGT/PLT in Patients with Chronic Liver Disease Complicated with Mood Disorder

目的:探究慢性肝病合并情绪障碍患者肝纤维化血生化指标与周围血细胞计数、γ-谷氨酰转移酶/血小板(GGT/PLT)比值的相关性。方法:收集2020年4月—2022年3月期间在我院确诊为慢性肝病合并情绪障碍患者103例,作为实验组;另同期收集性别与年龄匹配的健康体检者103例,作为参照组。均检测肝纤维化血生化指标血清透明质酸酶(HA)、Ⅲ型前胶原氨端肽/Ⅲ型前胶原(PⅢNP)、层粘连蛋白(LN)、Ⅳ型胶原(Ⅳ-C),周围血细胞计数红细胞(RBC)、白细胞(WBC)、血小板(PLT)、血红蛋白(HB)与γ-谷氨酰转移酶(GGT),并计算GGT/PLT比值。比较两组肝纤维化血生化指标,周围血细胞计数水平与GGT/PLT比值水平,并以Spearson分析相关性。结果:实验组肝纤维化血生化指标HA、PⅢNP、LN、Ⅳ-C水平均高于参照组(P<0.05);实验组周围血细胞计数RBC、WBC、HB、PLT水平均低于参照组,而GGT/PLT比值高于参照组(P<0.05);肝纤维化血生化指标HA、PⅢNP、LN、Ⅳ-C均与GGT/PLT比值呈正性相关(P<0.05),与周围血细胞计数RBC、WBC、HB、PLT呈负性相关(P<0.05)。结论:慢性肝病合并情绪障碍患者肝纤维化血生化指标与周围血细胞计数负性相关,与GGT/PLT比值正性相关,表示周围血细胞计数降低、GGT/PLT比值升高均反映肝纤维化加重,有望成为肝纤维化血生化指标诊断的替代物,值得深入研究。

Objective:To explore the correlation between blood biochemical indexes of liver fibrosis and peripheral blood count,γ-glutamyltransferase/platelet(GGT/PLT)ratio in patients with chronic liver disease complicated with mood disorder.Methods:A total of 103 patients diagnosed with chronic liver disease complicated with mood disorder in our hospital from April 2020 to March 2022 were collected as the experimental group.During the same period,103 healthy subjects with matched sex and age were collected as the reference group.Serum hyaluronidase(HA),typeⅢprocollagen aminopeptide/typeⅢprocollagen(PⅢNP),laminin(LN),typeⅳcollagen(ⅳ-c)were detected.Peripheral blood cells were counted red blood cells(RBC),white blood cells(WBC),platelets(PLT),hemoglobin(HB)andγ-glutamyltransferase(GGT),and GGT/PLT ratio was calculated.The blood biochemical indexes,peripheral blood count and GGT/PLT ratio were compared between the two groups,and the correlation was analyzed by Spearson.Results:The levels of HA,PⅢNP,LN andⅳ-c in the experimental group were higher than those in the control group(P<0.05).The levels of RBC,WBC,HB and PLT in peripheral blood cells of the experimental group were lower than those of the reference group,while GGT/PLT ratio was higher than that of the reference group(P<0.05).Serum biochemical indexes of liver fibrosis,such as HA,PⅢNP,LN andⅳ-c,were positively correlated with GGT/PLT ratio(P<0.05),and negatively correlated with peripheral blood count RBC,WBC,HB and PLT(P<0.05).Conclusions:Blood biochemical indexes of liver fibrosis in patients with chronic liver disease complicated with mood disorder were negatively correlated with peripheral blood count,and positively correlated with GGT/PLT ratio,indicating that decreased peripheral blood count and increased GGT/PLT ratio both reflect the aggravation of liver fibrosis,which is expected to be a substitute for blood biochemical indexes of liver fibrosis diagnosis,and worthy of further study.