胃癌与幽门螺杆菌感染的相关性研究

Study on the Correlation between Gastric Cancer and Helicobacter Pylori Infection

目的:分析胃癌与幽门螺杆菌感染的相关性。方法:将我院2020年7月—2021年6月诊治的80例患者作为研究对象,按照不同的疾病分为2组,分组比例为1∶1,对照组为慢性胃炎、消化道溃疡等非胃癌疾病患者,观察组为胃癌疾病患者。对胃癌患者幽门螺杆菌感染情况行单因素分析,并分析胃癌患者幽门螺杆菌感染的危险因素。经过治疗后分析胃癌患者病情与幽门螺杆菌的相关性。结果:观察组胃镜、碳-14尿素呼气试验检查幽门螺杆菌感染率高于对照组,差异有统计学意义(P<0.05)。对照组中慢性炎症性病变、胃黏膜萎缩、肠上皮化生、不典型增生等不同病变程度患者的幽门螺杆菌感染率依次递增,差异无统计学意义(P>0.05)。观察组中早期胃癌的螺杆菌感染率高于进展期胃癌,肠型胃癌幽门螺杆菌感染率高于弥漫型,非贲门部胃癌的螺杆菌感染率高于贲门部,差异有统计学意义(P<0.05)。Logistic回归分析,结果显示胃癌患者不同时期、不同分型、不同部位是幽门螺杆菌感染的危险因素。胃癌患者病情与幽门螺杆菌呈正相关。结论:幽门螺杆菌感染与胃癌病情程度呈正相关,临床应尽早对消化道疾病患者实施幽门螺杆菌筛查,并予以治疗,可减少胃癌发生的风险。

Objective:To analyze the correlation between gastric cancer and helicobacter pylori infection.Methods:A total of 80 patients diagnosed and treated in our hospital from July 2020 to June 2021 were selected as the research object.According to different diseases,they were divided into 2 groups,the grouping ratio was 1∶1,the control group was patients with chronic gastritis,gastrointestinal ulcer and other non-gastric cancer diseases,and the observation group was patients with gastric cancer diseases.Single factor analysis was performed on helicobacter pylori infection in patients with gastric cancer,and risk factors of helicobacter pylori infection were analyzed.After treatment,the correlation between the disease of gastric cancer patients and Helicobacter pylori was analyzed.Results:The infection rate of Helicobacter pylori detected by gastroscopy and carbon-14 urea breath test in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).In the control group,the infection rate of Helicobacter pylori in patients with chronic inflammatory lesions,gastric mucosal atrophy,intestinal metaplasia and atypical hyperplasia increased successively,and there was no statistical significance(P>0.05).In the observation group,the helicobacter infection rate of early gastric cancer was higher than that of advanced gastric cancer, the helicobacter pylori infection rate of intestinal gastric cancer was higher than that of diffuse gastric cancer, and the helicobacter infection rate of non-cardia gastric cancer was higher than that of cardia, with statistical significance ( P <0.05). Logistic regression analysis, the results showed that different stages, types and locations of gastric cancer patients were risk factors for H. pylori infection. The disease of cancer patients was positively correlated with Helicobacter pylori. Conclusion: Helicobacter pylori infection is positively correlated with the severity of gastric cancer. Helicobacter pylori screening and treatment should be carried out in patients with digestive tract diseases as soon as possible, which can reduce the risk of gastric cancer.