丹参多酚酸盐治疗冠心病心绞痛患者的临床效果观察

Clinical Effect of Salvia Miltiorrhiza Polyphenolate on Patients with CoronaryHeart Disease and Angina Pectoris

目的:探讨丹参多酚酸盐治疗冠心病心绞痛患者的临床效果。方法:本研究的观察对象为冠心病心绞痛患者,收集时间为2019年5月到2021年2月,共128例。将所有观察对象遵循随机数字表法分组:对照组(n=64)、治疗组(n=64)。对照组服用艾司洛尔,治疗组在服用艾司洛尔的基础上加用丹参多酚酸盐。评价治疗效果,比较治疗前后心绞痛发作次数及时间,检测比较治疗前后血管内皮功能及氧化应激损伤指标。结果:与对照组比较,治疗组总有效率显著提高(92.19%VS 79.69%,P<0.05)。两组患者经过治疗后,心绞痛每周发作次数及每次发作时间均降低(P<0.05);与对照组比较,治疗组治疗后心绞痛每周发作次数及每次发作时间降低明显(P<0.05)。两组患者经过治疗后,SOD水平均升高,ET-1、MDA水平均降低(P<0.05);与对照组比较,治疗组治疗后SOD水平升高更显著,ET-1、MDA水平降低更显著(P<0.05)。结论:冠心病心绞痛患者应用丹参多酚酸盐可以改善临床症状,提高治疗效果,考虑药物作用机制可能与改善血管内皮功能、减轻机体氧化应激损伤有关。

Objective:To explore the clinical effect of Salvia miltiorrhiza polyphenolate in the treatment of coronary heart disease and angina pectoris.Method:128 patients with coronary heart disease and angina pectoris were selected.The collection time was from May 2019 to February 2021,a total of 128 cases.They were divided into two groups according to the random number table method:control group(n=64)and treatment group(n=64).The control group took esmolol,and the treatment group added Salvia miltiorrhiza polyphenolic acid salt on the basis of taking esmolol.Evaluate the treatment effect,compare the number and time of angina pectoris attack before and after treatment,detect and compare the vascular endothelial function and oxidative stress injury indexes before and after treatment.Result:Compared with the control group,the total effective rate of the treatment group was significantly improved(92.19%VS 79.69%,P<0.05).After treatment,the number of angina pectoris attacks per week and the time of each attack decreased in both groups(P<0.05);Compared with the control group,the number of angina pectoris attacks per week and the time of each attack in the treatment group decreased significantly after treatment(P<0.05).After treatment,the levels of SOD in the two groups were higher than those before treatment,and the levels of ET-1 and MDA were lower than those before treatment(P<0.05);Compared with the control group,the level of SOD in the treatment group increased more significantly after treatment,and the levels of ET-1 and MDA decreased more significantly(P<0.05).Conclusion:Salvia miltiorrhiza polyphenolate can improve the clinical symptoms of patients with coronary heart disease and angina pectoris and improve the therapeutic effect.Considering the mechanism of drug action,it may be related to improving vascular endothelial function and reducing oxidative stress injury.