自拟解毒疏肝组方对原发性肝癌介入术后综合征的疗效观察

Observation of the efficacy of self-prepared detoxification and hepatic de-escalation protocols in the postoperative syndrome of primary hepatocellular carcinoma intervention

[目的]探讨自拟解毒疏肝组方对原发性肝癌介入术后综合征的疗效。[方法]选取原发性肝癌患者90例作为研究对象,按随机数字表法分为研究组和对照组,每组各45例,2组均行介入治疗。对照组行常规西药对症治疗,研究组于术前术后给予自拟解毒疏肝组方治疗。观察并比较2组术后综合征各症状持续时间及安全性,评估并比较治疗前后2组患者中医症候积分、肝功能、卡氏评分(KPS评分)。[结果]研究组与对照组术前4 d KPS评分及肝功能、术后1 d中医症候积分比较均差异无统计学意义(P>0.05)。术后28 d研究组中医症候积分明显低于对照组,KPS评分明显高于对照组,差异有统计学意义(P<0.05)。术后28 d,研究组与对照组无肾功能异常、2组在血常规异常上比较差异无统计学意义(P>0.05);2组ALT、AST、TBil较术前4 d有明显增高(P<0.05),研究组ALT、AST、TBil均低于对照组,差异具有统计学意义(t=3.834、4.512、2.869,P<0.05)。[结论]自拟解毒疏肝组方应用于原发性肝癌介入术后综合征有助于改善中医临床证候及肝功能,缩短发热、肝区疼痛等症状持续时间,提高机体抗肿瘤能力。

[Objective]To investigate the efficacy of self-prescribed detoxification and hepatic de-escalation formulations in postoperative syndrome of primary hepatocellular carcinoma intervention [Methods]The ninety cases of primary liver cancer patients were selected as study subjects.All patients were divided into experimental and control groups according to the random number table method, 45 cases in each group.Both groups underwent interventional treatment, while the control group underwent symptomatic treatment with conventional western medicine;the experimental group underwent preoperative and postoperative Chinese medicine treatment with self-prescribed detoxification and liver dredging group.The duration and safety of each symptom of postoperative syndrome between the two groups were observed and compared.The Chinese medicine symptom score, liver function, KPS before and after treatment in two groups of patients were assessed and compared.[Results]No statistically significant difference between the two groups in KPS score and liver function at 4 d preoperatively and Chinese medicine symptom score at 1 d postoperatively(P>0.05).The postoperative KPS scores were significantly higher in the 28 d in experimental group than in the control group, and the difference was statistically significant(P<0.05).The postoperative 28 d in experimental group had a significantly lower Chinese medicine symptom score than the control group.There was no renal function abnormality in the two groups at 28 d after surgery, and the difference between the two groups was not statistically significant(P>0.05).After treatment, the ALT,AST and TBil were significantly higher in both groups at 4 weeks postoperatively compared to 4 days preoperatively.The ALT,AST,TBil were all lower in the postoperative 28 d experimental group than in the control group.The difference between the two groups was statistically significant(t=3.834,4.512,2.869,P<0.05).[Conclusion]The self-prepared detoxification and hepatic dredging formula can help improve the clinical evidence and liver function of TCM,shorten the duration of symptoms such as fever and pain in the liver area, and improve the anti-tumor ability of the body.