房室结折返性心动过速的遗传学研究进展

Progress in genetics of atrioventricular nodal reentrant tachycardia

房室结折返性心动过速(AVNRT)是临床中最常见的一种阵发性室上性心动过速,其发病机制至今仍未阐明。既往认为AVNRT与先天性心脏传导通路发育异常有关。近年来,随着家族性AVNRT不断报道,提示该病与遗传因素有关,新近的基因测序结果显示离子通道相关基因突变可能与其发生有关。本文将对AVNRT的遗传学研究进行综述。

Atrioventricular nodal reentrant tachycardia(AVNRT)is the most common kind of paroxysmal supraventricular tachycardia(PSVT),but its underlying mechanism is not clear.It was considered as congenital cardiac conduction pathway in the past years.Recently,familial AVNRT and candidate pathogenic genes/pathways indicate association with genetic factors.Therefore,the aim of this study is to summarize the genetic research of AVNRT.