近视视网膜病变与CaMKKβ/AMPK信号通路的相关性

Research progress on the correlation between myopic retinopathy and CaMKKβ/AMPK signaling pathway

多项研究发现,目前近视的患病率在全球范围内成爆发性增长,且逐渐呈低龄化趋势。伴随着近视进展,屈光度不断增加、眼轴进行性的延长会引起一系列的眼部并发症,例如视网膜萎缩、视网膜脱离、视网膜变薄及撕裂等。Ca^(2+)/钙调蛋白活化的蛋白激酶-β(Ca^(2+)/calmodulin-dependent protein kinase kinaseβ,CaMKKβ)/腺苷单磷酸激活的蛋白激酶(adenosine monophosphate-activated protein kinase,AMPK)信号通路是调节细胞能量代谢的经典途径之一,CaMKKβ响应于Ca^(2+)的增加而通过磷酸化激活AMPK,进一步激活自噬。近期研究发现近视视网膜病变与CaMKKβ/AMPK信号通路密切相关,故本文将主要探讨和介绍近视患者的视网膜病变与CaMKKβ/AMPK信号通路的相关性。

A number of researches have found that the current incidence of myopia has been increasing explosively and globally,moreover,which shows a trend of younger age.With the progress of myopia,the increasing refractive power and the progressive lengthening of the eye axis will cause a series of ocular complications,including retinal atrophy,retinal detachment,thinning and tearing of the retina.The CaMKKβ/AMPK signaling pathway is one of the classical pathways that regulate cellular energy metabolism,and CaMKKβactivates Ca^(2+) in response to an increase in Ca^(2+) by phosphorylating AMPK,further to activate autophagy.Recent researches have found that myopic retinopathy is closely related to CaMKKβ/AMPK signaling pathway,so this article will explore the correlation between retinopathy and CaMKKβ/AMPK signaling pathway in patients with myopia.