肠道菌群在帕金森病发病过程中作用的研究进展

Research progress on the role of gut microbiota in the pathogenesis of Parkinson's disease

帕金森病(PD)是一种常见的神经退行性疾病。PD患者肠道菌群变化显著。越来越多的研究表明肠道菌群与PD的发生、发展密切相关。PD特征性的病理改变是中脑黑质多巴胺能神经元死亡和残存神经元细胞质及突触中含有α-突触核蛋白的路易小体。本文对PD患者肠道菌群改变及其在PD发病过程中的神经炎症及α-突触核蛋白的改变中的作用进行了综述,为以肠道菌群作为靶点治疗PD的研究提供参考。

Parkinson’s disease(PD)is a common neurodegeneration disease.The gut microbiota of PD patients changed significantly.An increasing number of studies have shown gut microbiota is closely related to the occurrence and development of PD.The characteristic pathological changes of PD are the death of dopaminergic neurons in the substantia nigra and the Lewy bodies containingα-synuclein in the cytoplasm and synapse of the surviving neurons.This article reviews the changes of gut microbiota in PD patients and its role in the pathogenesis of PD,including involvement in neuroinflammation andα-synclein changes of PD,to provide references for the study of gut microbiota as a potential target for PD therapy.