摘要
目的探讨罗氏内异方与短效口服避孕药在卵巢子宫内膜异位囊肿患者的术后维持治疗中是否具有同等的临床应用价值。方法选取Ⅲ期卵巢子宫内膜异位囊肿病例共106例,口服避孕药组56例,罗氏内异方组50例,在术前、术后2、4、6个月4个时间点分别监测糖类抗原125(CA-125)、疼痛视觉模拟评分(VAS评分)、抗苗勒氏管激素(AMH),并计算术后6个月时的复发率,将各观察指标进行两组间统计学比较分析。结果罗氏内异方组和口服避孕药组的术后CA-125、VAS疼痛评分、AMH等指标的术后6个月连续测量资料的整体趋势比较差异均无统计学意义(P>0.10)。两组术后半年的复发率比较差异也无统计学意义(P=0.908)。口服避孕药组的CA-125术后2个月内的下降速率快于罗氏内异方组,但术后半年时差异无统计学意义。其他指标的术后下降速率两组间差异无统计学意义。两组均无严重不良反应发生。结论罗氏内异方在巧囊术后6个月的维持治疗中具有和口服避孕药同等的疗效和临床应用价值。
Objective To investigate whether Luo′s Endometriosis Formula and combined oral contraceptives are equally effective in postoperative maintenance treatment for patients with ovarian endometriomas.Methods A total of 106 cases with stageⅢovarian endometriomas were enrolled in this study,including 56 patients in the combined oral contraceptive group and 50 patients in the Luo′s Endometriosis Formula group.Carbohydrate antigen 125(CA-125),visual analog scale(VAS)scores and antimullerin hormone(AMH)were monitored before surgery,2 months after surgery,4 months after surgery and 6 months after surgery,respectively.The recurrence rate at 6 months after surgery was calculated,and statistical analysis was performed for each observation index between the two groups.Results Six months after surgery,there was no statistical difference in the overall trend of postoperative CA-125,VAS score,and AMH between the Luo′s Endometriosis Formula group and the combined oral contraceptive group(P>0.10).Six months after surgery,there was no significant difference in recurrence rate between the two groups(P=0.908).The combined oral contraceptive group′s CA-125 decline rate was faster than the Luo′s Endometriosis Formula group′s in the first two months after surgery,but there was no statistical difference six months later.Other indexes′postoperative decline rates did not differ significantly between the two groups.There were no serious adverse reactions in either group.Conclusions Luo′s Endometriosis Formula has the same curative effect and clinical application value as combined oral contraceptives in the maintenance treatment of ovarian endometriomas 6 months after cystectomy.
作者
高克非
曾根
袁烁
卢如玲
李思瑾
杜苗苗
赵二勇
易莉莎
刘雅琼
陈微微
何小倩
邱嘉菡
卜亚丽
杨川子
GAO Ke-fei;ZENG Gen;YUAN Shuo;LU Ruling;LI Sijin;DU Miaomiao;ZHAO Eryong;YI Lisha;LIU Yaqiong;CHEN Weiwei;HE Xiaoqian;QIU Jiahan;BU Yali;YANG Chuanzi(Department of Gynecology,Guangzhou Women and Children′s Medical Center,Guangzhou 510623,China)
出处
《实用医学杂志》
CAS
北大核心
2022年第16期2086-2093,共8页
The Journal of Practical Medicine
基金
广东省中医药局中医药科研项目基金资助项目(编号:20201299)
广州市卫生健康科技项目西医类一般引导项目资助项目(编号:20221A011026)。
关键词
罗氏内异方
口服避孕药
卵巢子宫内膜异位囊肿
维持治疗
Luo′s Endometriosis Formula
combined oral contraceptive
ovarian endometrioma
maintenance treatment