拉曼光谱技术在肾脏病变鉴别诊断的应用进展

Progress on Raman spectroscopy for differential diagnosis of renal diseases

老年人群肾脏疾病患病率正在逐年升高,肾脏具有维持内环境稳定及内分泌功能,肾脏功能受损可引起各系统症状,目前肾脏疾病检查主要包括尿液检查、肾功能检查、影像学检查和肾脏病理学检查等,但由于其通常起病隐匿,早期诊断仍存在一定困难。临床研究中不断探索合适的肾脏标志物、检查方式以期能更早发现肾脏病变。随着拉曼光谱技术的发展,其可用于评估生物组织或液体的分子组成,从而获取具有诊断价值的定性或定量信息,并因其无创性等优点,在早期临床诊断方面表现出巨大潜力。本文就拉曼光谱技术在肾脏疾病诊断方面的应用及潜力作一综述。

Objective The prevalence of renal diseases in the elderly population is increasing yearly.Kidney maintains the stability of the internal environment and normal endocrine function,and impaired kidney function can cause symptoms in various systems.Clinical research continues to explore suitable kidney markers and methods to detect kidney lesions earlier.With the development of Raman spectroscopy,it can be used to assess the molecular composition of biological tissues or fluids to obtain qualitative or quantitative information with diagnostic value.It also has shown great potential for early clinical diagnosis due to its non-invasive nature and other advantages.In this paper,we describe the application and potential of Raman spectroscopy in diagnosing renal diseases.