MRI多模式影像下溶栓治疗急性脑卒中

Clinical study on thrombolytic therapy for acute stroke under MRI multi-mode image

目的研究磁共振成像(MRI)多模式影像下溶栓治疗急性脑卒中的临床价值。方法选择脑卒中患者50例,按MRI多模式影像检测结果分为超时间窗组及时间窗内组。时间窗内组采用静脉溶栓治疗,超时间窗组采用常规抗凝等治疗,2组均在治疗1个月后复查。检测2组白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平,采用脑梗死溶栓分级(TICI)评估血管再通情况,采用美国国立卫生研究院卒中量表(NIHSS)评估神经受损情况,采用Fugl Meyer运动功能量表(FMA)、躯干控制量表(Sheikh)评估神经功能恢复情况,统计不良反应发生情况。结果时间窗内组治疗后IL-6、hs-CRP水平均低于超时间窗组(P<0.05);时间窗内组血管再通情况优于超时间窗组(P<0.05);时间窗内组治疗后NIHSS评分均低于超时间窗组(P<0.05);时间窗内组治疗后FMA、Sheikh评分高于超时间窗组(P<0.05);2组不良反应发生率无统计学差异(P>0.05)。结论在MRI多模式影像下溶栓治疗急性脑卒,可有效改善神经功能及神经恢复功能。

Objective To study the clinical values of thrombolysis in the treatment of acute stroke under the magnetic resonance imaging(MRI)multi-mode image.Methods A total of 50 stroke patients were enrolled in the study and divided into an over-time window group and an in-time window group according to the detection results of the MRI multi-mode image.The in-time window group was given an intravenous thrombolysis,while the over-time window group was given a routine anticoagulant therapy.Both groups were reviewed one month after treatment.The levels of interleukin-6(IL-6)and high-sensitivity C-reactive protein(hs-CRP)in both groups were measured.The thrombolysis in cerebral infarction(TICI)was performed to evaluate the vascular recanalization.The National Institute of Health Stroke Scale(NIHSS)was performed to evaluate the neurological impairment.The recovery of the neurological function was evaluated by the Fugl-Meyer Assessment(FMA)and Sheikh Trunk Control Scale(Sheikh).The incidence of adverse reactions was statistically analyzed.Results After treatment,the levels of IL-6 and hs-CRP in the in-time window group were lower than those in the over-time window group(P<0.05).The vascular recanalization in the in-time window group was better than that in the over-time window group(P<0.05),while the NIHSS scores were lower than those in the over-time window group(P<0.05).After treatment,the FMA and Sheikh scores in the in-time window group were higher than those in the over-time window group(P<0.05).There was no signi?cant di?erence in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The thrombolytic therapy for acute stroke under the MRI multi-mode image can effectively improve the neurological function and the recovery of the neurological function.