铁超载在骨关节炎发生发展中的作用机制研究进展

Research progress on the mechanism of iron overload in the occurrence and development of osteoarthritis

骨关节炎(osteoarthritis,OA)是一种常见的慢性退行性疾病,其病情随年龄增长呈不断加重趋势。OA发病机制复杂,许多危险因素均可导致OA的发生。铁作为机体必不可少的微量元素之一,其代谢平衡对人体的健康极其重要。铁超载与OA的发生发展密切相关,关节组织中过多的铁沉积易导致关节软骨和滑膜发生病变以及影响软骨下骨重建导致OA的发生。笔者查阅近几年相关研究文献,就铁超载在OA发生发展过程中的作用机制展开综述,以期为OA发病研究及诊治策略提供新的思路和方向。

Osteoarthritis(OA)is a common chronic degenerative disease,and its condition tends to worsen with age.The pathogenesis of OA is complex,and many risk factors can lead to the occurrence of OA.Iron is one of the essential trace elements in the body,and its metabolic balance is extremely important to human health.Iron overload is closely related to the occurrence and development of OA.Excessive iron deposition in joint tissue can easily lead to lesions of articular cartilage and synovium,as well as affect subchondral bone reconstruction and lead to the occurrence of OA.The author reviewed the relevant research literature in recent years,and reviewed the mechanism of iron overload in the occurrence and development of OA,in order to provide new ideas and directions for the research and diagnosis and treatment of OA.