天津市输入型新型冠状病毒奥密克戎变异毒株感染者的临床特征分析

Clinical characteristics of persons infected with imported SARS-CoV-2 Omicron variant in Tianjin

目的探讨感染新型冠状病毒奥密克戎变异毒株的流行病学、临床及影像学特点。方法回顾性分析52例输入型奥密克戎变异毒株感染者的临床与影像学资料,根据住院期间胸部CT有无肺炎表现,将纳入对象分为无肺炎表现组(26例)及有肺炎表现组(26例),比较2组临床表现、实验室指标的特点;根据患者住院期间胸部CT是否进展将有肺炎表现组分为进展组(13例)和无进展组(13例),比较2个亚组实验室指标及影像学征象的特点。结果52例中以男性为主(71.2%);中位年龄29.5(24.0,42.5)岁,且有肺炎表现组的年龄较高(P<0.05);新型冠状病毒疫苗接种率90.4%;主要症状为咳嗽(50%)、咽干咽痛(48.1%)、发热(44.2%),无肺炎表现组和有肺炎表现组疫苗接种史、临床表现及白细胞计数、C反应蛋白、降钙素原、白细胞介素6、D-二聚体和T细胞亚群比较差异无统计学意义;52例中胸部CT异常者占50%,其中较常见的CT征象有磨玻璃密度影(GGO,88.5%)、实变影(50.0%)、胸膜增厚(30.8%)。进展组更容易出现实变影和多肺叶受累。结论输入型奥密克戎变异毒株感染者症状以咳嗽、咽干咽痛、发热较为常见;胸部CT最常见的征象为GGO,可用来对疾病进行早期诊断及病情评估。

Objective To investigate the epidemiological,clinical and imaging characteristics of SARS-CoV-2 infection caused by Omicron variant.Methods The clinical and imaging data of 52 cases infected with imported Omicron variant were retrospectively reviewed.According to the chest CT findings,the cases were divided into 2 groups:the unaltered group(n=26)and abnormal group(n=26).The characteristics of clinical manifestations and laboratory indicators were compared between the two groups.According to the progress of chest CT during hospitalization,patients in the abnormal group were divided into two subgroups:the improved subgroup(n=13)and the progress subgroup(n=13).The clinical and imaging characteristics were compared between the two subgroups.Results In the 52 cases,males accounted for 71.2%.The average age was 29.5(24.0,42.5),and the average age was older in the abnormal group(P<0.05).Vaccination rate was 90.4%,with the main symptoms of cough(50%),dry sore throat(48.1%)and fever(44.2%).There were no significant differences in vaccination rate,symptoms,the level of leukocytes,C-reactive proteins,calcitonogen,interleukin-6,D-dimers and T lymphocytes between the two groups.Among 52 cases,chest CT abnormalities accounted for 50%,among which the most common CT sighs were ground-glass opacity(GGO,88.5%),consolidation shadow(50.0%)and pleural thickening(30.8%).The progressive group was more likely to have consolidation changes and multiple lobar involvement.Conclusion Cough,throat discomfort and fever are the most common symptoms.The most common chest imaging finding is GGO,which can be used to the early diagnosis and assessment of the disease.