Gal-3参与阿尔茨海默病的机制研究进展

Research progress on the role of Gal-3 in Alzheimer′s disease

半乳糖凝集素-3(Gal-3)属半乳糖苷凝集素家族,表达于神经系统,可结合多种分子,通过调节下游信号发挥作用。在阿尔茨海默病(AD)患者的病变脑区、血清和脑脊液中,Gal-3的表达变化与AD病变进程相关。因此,Gal-3有望成为AD诊断与检测药物疗效的重要生物标志物。该文就Gal-3参与AD的分子机制研究进展进行综述,以期为AD的诊断、治疗及药物研发提供新观点。

Galectin-3(Gal-3),widely expressed in central nervous system,is a member of the galectin family.Gal-3 can bind a variety of molecules and play a role by regulating downstream signals.Recent advances have suggested that changes in Gal-3 expression in brain tissues,serum and cerebrospinal fluid of patients with Alzheimer′s disease(AD)are closely related to the severity of AD.Therefore,GAL-3 is expected to be an important biomarker for the diagnosis and detection of drug efficacy in AD.In this review,we present an updated overview of the current understanding of Gal-3 involvement in AD,which may provide useful references for the clinical diagnosis and treatment of AD in the future.