功能红曲液态发酵的研究进展

Research progress of submerged fermentation of functional Monascus

红曲菌液态发酵可以产生众多的次级代谢产物,尤其以功能红曲Monacolin K及其类似物为代表的活性物质,为当今研究的重点。该文概述了Monacolin K的生物活性与生物合成,以及功能红曲液态发酵的控制策略,重点分析了在红曲菌液态发酵中,通过菌种筛选、培养基构建、补料工艺构建、发酵条件构建、代谢途径控制方法构建等方面来提高Monacolin K产量的途径。同时,对当前功能红曲行业的现状、以不含甘油的原料为碳源的液态发酵如何突破低产Monacolin K的瓶颈和相关政策法规的完善进行了探讨。

Monascus submerged fermentation can produce many secondary metabolites,especially the active substances represented by functional Monacolin K and its analogues,which are the focus of current research.The research studied the bioactivity and biosynthesis of Monacolin K and the control strategy of submerged fermentation of functional Monascus,focused on the methods to improve the yield of Monacolin K including strain screening,culture medium optimization,feeding process,fermentation conditions,metabolic pathway control method construction,etc.At the same time,current situation of functional Monascus industry is prospected,how to break through the bottleneck of low-yield Monacolin K with glycerol-free raw materials as carbon sources is discussed,as well as the existing problems of relevant policies and regulations in the industry.