阿帕替尼对晚期肺癌患者癌胚抗原和糖类抗原水平的影响

Effects of apatinib on carcinoembryonic antigen and cancer antigen 125 levels in patients with advanced lung cancer

目的 探讨阿帕替尼对晚期肺癌患者癌胚抗原和糖类抗原水平的影响。方法 选取2018年1月至2019年11月间长阳土家族自治县人民医院收治的100例晚期肺癌患者,随机分为研究组和对照组,每组50例。研究组患者采用阿帕替尼治疗,对照组患者采用替吉奥治疗,比较两组患者细胞因子水平变化、临床疗效、体力及生活质量评分和血清肿瘤标志物水平。结果 治疗后,研究组肿瘤坏死因子α、白介素4和γ干扰素等指标水平改善程度均较对照组高,差异均有统计学意义(均P<0.05)。研究组患者治疗有效率为88.0%,高于对照组的62.0%,差异有统计学意义(P<0.05)。研究组患者的卡式功能评分和生活质量测定量表评分均高于对照组,差异均有统计学意义(均P<0.05)。治疗后,研究组患者癌胚抗原和糖类抗原(CA)125及CA199等水平均低于对照组,差异均有统计学意义(均P<0.05)。结论 晚期肺癌患者采用阿帕替尼干预治疗,可有效增强治疗疗效,降低血清肿瘤标志物及细胞因子水平,增强体力,促进生活质量改善,可推广使用。

Objective To investigate the effects of apatinib on carcinoembryonic antigen(CEA) and cancer antigen 125(CA125) levels in patients with advanced lung cancer. Methods A total of 100 patients with advanced lung cancer admitted to Changyang Tujia Autonomous County People’s Hospital were selected from January 2018 to November 2019. They were randomly divided into an experimental group and a control group with 50 patients in each group. The experimental group received apatinib and the control group received tegafur. Changes in cytokine levels, therapeutic efficacy, physical strength, quality of life scores and serum tumor markers were compared between the two groups. Results After the treatment, improvement in the levels of tumor necrosis factor-α, interleukin-4 and interferon-γ were relatively higher in the experimental group than in the control group(all P<0.05). The therapeutic efficacy was 88.0% in the experimental group which was higher than 62.0% of the control group(P<0.05). Karnofsky performance status score and quality of life score were higher in the experimental group than in the control group(P<0.05). After the treatment, the levels of CEA, CA125 and CA199 were significantly lower in the experimental group than in the control group(all P<0.05). Conclusion Apatinib can effectively enhance the therapeutic efficacy for advanced lung cancer. It reduces the levels of various serum tumor markers and cytokines, significantly enhance the physical strength, and improves quality of life, and can be popularized in practice.