肠道菌群与免疫相关疾病

Gut microbiota and immune-related diseases

肠道菌群与宿主免疫反应之间存在直接和间接的相互作用, 能够对宿主健康产生多方面的影响。肠道菌群紊乱导致的生态失调与许多疾病的易感性有关, 特别是免疫相关性疾病。本文根据近年来的研究结果, 介绍了肠道菌群与宿主免疫相互作用的机制, 阐述了肠道菌群在免疫相关性疾病发生发展中的作用, 包括炎性肠病等肠道系统疾病以及类风湿关节炎等其他系统疾病, 并总结了以肠道菌群为靶点的疾病治疗策略。更好地了解肠道菌群与免疫相关性疾病的研究进展, 将有助于此类疾病的预防和管理工作, 并拓宽我们发现疾病干预靶点的路径。

There are direct and indirect interactions between gut microbiota and host immune response,which can have a multifaceted impact on host health.Dysbiosis caused by disturbances in the gut microbiota is associated with susceptibility to many diseases,especially immune-related diseases.Based on the research results in recent years,this paper introduced the mechanism of the interaction between gut microbiota and host immunity,and expounded the role of gut microbiota in the occurrence and development of immune-related diseases,including intestinal system diseases such as inflammatory bowel disease and other systemic diseases such as rheumatoid arthritis,and summarized disease treatment strategies targeting gut microbiota.A better understanding of the research progress of gut microbiota and immune-related diseases will help us in the prevention and management of such diseases,and broaden our path to discover disease intervention targets.