摘要
Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stemcells. They recapitulate cell-cell, cell-niche interactions in tissue development, homeostasis, regeneration anddisease, and provide an in vitro model for drug screening. This review summarizes the recent advances of organoidcultures derived from adult lung stem cells and human pluripotent stem cells, especially focusing on the organoidsof the distal airway stem/progenitor cells. We also discuss the applications of organoids in studying lungregeneration and pulmonary diseases, including pulmonary fibrosis, airway diseases and Coronavirus disease 2019(COVID-19).
基金
This work was supported by the National Natural Science Foundation of China(Grant 82070065 to Y.X.)
Shanghai Pujiang Program(Grant 20PJ1410800 to Y.X.)from Science and Technology Commission of Shanghai Municipality and Shanghai Municipal Human Resources and Social Security Bureau,and ShanghaiTech University star-up funds(to Y.X.).
