基于肠道菌群探讨中医从脾论治老年性痴呆的研究进展

Discussion on the treatment of Alzheimer’s disease from the spleen based on intestinal flora

老年性痴呆(alzheimer′s disease,AD)是一种临床上常见的中枢神经系统退行性变性疾病,发病机制复杂,严重危害老年人身心健康。近年来大量研究表明,肠道菌群可以通过脑-肠轴对中枢神经系统进行调控,从而参与AD的发生、发展。老年性痴呆属中医学“痴呆”、“善忘”范畴,由七情内伤、年老久病等致气血不足、肾精亏虚、痰瘀阻滞,使脑消髓减、神机失用,多从心肝肾论治。我们认为痰浊瘀血阻窍是AD的病机关键,当从脾论治,并针对病机特点提出温脾通络开窍法来防治AD。文章以肠道菌群为切入点,探讨中医从脾论治AD的研究进展。

Alzheimer′s disease(AD)is a clinically common degenerative disease of the central nervous system with a complex pathogenesis,which seriously endangers the physical and mental health of the elderly. In recent years,a large number of studies have shown that the intestinal flora can regulate the central nervous system through the brain-gut axis,thereby participating in the occurrence and development of AD. AD belongs to the category of "dementia" and "forgetfulness" in traditional Chinese medicine. It is caused by internal injury of seven emotions,old age and chronic illness,which can cause insufficient blood,deficiency of kidney essence,and blockage of phlegm and blood. To use,treat more from the heart,liver and kidney. We believe that phlegm turbidity blocking the orifice is the key to the pathogenesis of AD. It should be treated from the spleen,and according to the characteristics of the pathogenesis,the method of warming the spleen and dredging the collaterals and resuscitation is proposed to prevent AD. This article takes the intestinal flora as the starting point to discuss the research progress of treating AD from the spleen.